PK fixture parameter provenance inventory

この一覧は drugs/*/pk.yml、targets.yml、spec_pk1_*.yml を読み取り、値の由来を確認するための監査用出力です。ソースURLが存在することだけでは、URL内のどの記載が特定の値に対応するかを証明しません。reference_status を必ず確認してください。

読み方

  • value_level_metadata: pk.yml.value_provenance に解決済みsource_idがあり、source_review_status=checked。
  • value_level_metadata_needs_source_mapping: value_provenanceはあるが、値単位のsource_idが未記録。
  • value_level_metadata_needs_source_review: source_idはあるが、値単位のreviewが未完了。
  • source_mapping_status=checked: その行のsource_idと値単位reviewが確認済み。これ以外は直接の科学的根拠として扱わない。
  • mapped_to_pk_derived: specのCL/Vが pk.yml.derived と一致する。
  • derived_from_pk_yml_source_fields: pk.yml内のparsed値から導出された値で、独立した直接報告値ではない。
  • source_url_present_not_parameter_mapped: URLはあるが、特定パラメータとの直接対応は未記録。
  • fixture_policy_*: デモ用specの仮定。外部文献値として扱わない。

CSVの全行は PARAMETER_PROVENANCE.csv、URLの全件は SOURCES.csv にあります。raw_*/normalized_*/pk_raw_excerpt/conversion_* と検証状態を併読してください。URL本文の直接引用や査読をこの一覧だけで代替しないでください。数値の変更はこの出力では行わず、canonicalなYAMLを更新してから再生成してください。

薬剤別サマリー

Drug Route Spec Source URLs Parameter rows Checked source-mapping rows Status
abciximab iv spec_pk1_iv.yml 6 17 7 source_urls_present
aciclovir po spec_pk1_oral.yml 5 21 7 source_urls_present
albuterol iv spec_pk1_iv.yml 1 17 7 source_urls_present
alfentanil iv spec_pk1_iv.yml 1 17 7 source_urls_present
alprazolam po spec_pk1_oral.yml 1 21 7 source_urls_present
amikacin iv spec_pk1_iv.yml 1 17 7 source_urls_present
apixaban po spec_pk1_oral.yml 1 21 7 source_urls_present
atazanavir po spec_pk1_oral.yml 2 18 7 source_urls_present
buprenorphine iv spec_pk1_iv.yml 1 17 7 source_urls_present
carbamazepine po spec_pk1_oral.yml 1 21 7 source_urls_present
cda1 iv spec_pk1_iv.yml 2 17 7 source_urls_present
cimetidine po spec_pk1_oral.yml 2 21 7 source_urls_present
clarithromycin po spec_pk1_oral.yml 3 21 7 source_urls_present
dapagliflozin po spec_pk1_oral.yml 1 21 7 source_urls_present
efavirenz po spec_pk1_oral.yml 2 18 7 source_urls_present
erythromycin iv spec_pk1_iv.yml 1 17 7 source_urls_present
ethinylestradiol po spec_pk1_oral.yml 2 21 7 source_urls_present
felodipine po spec_pk1_oral.yml 2 21 7 source_urls_present
fluconazole iv spec_pk1_iv.yml 1 17 7 source_urls_present
fluvoxamine po spec_pk1_oral.yml 8 21 7 source_urls_present
inulin iv spec_pk1_iv.yml 3 17 7 source_urls_present
itraconazole po spec_pk1_oral.yml 1 21 7 source_urls_present
mefenamic_acid po spec_pk1_oral.yml 2 18 7 source_urls_present
metoprolol po spec_pk1_oral.yml 2 21 7 source_urls_present
mexiletine po spec_pk1_oral.yml 2 21 7 source_urls_present
moclobemide po spec_pk1_oral.yml 5 21 7 source_urls_present
montelukast po spec_pk1_oral.yml 1 21 7 source_urls_present
motavizumab_medi_524 iv spec_pk1_iv.yml 1 17 7 source_urls_present
motavizumab_yte iv spec_pk1_iv.yml 1 17 7 source_urls_present
omeprazole po spec_pk1_oral.yml 4 21 7 source_urls_present
raltegravir po spec_pk1_oral.yml 2 21 7 source_urls_present
sildenafil po spec_pk1_oral.yml 6 21 7 source_urls_present
sufentanil sl spec_pk1_oral.yml 1 21 7 source_urls_present
tefibazumab iv spec_pk1_iv.yml 1 17 7 source_urls_present
tizanidine po spec_pk1_oral.yml 1 21 7 source_urls_present
triazolam po spec_pk1_oral.yml 3 21 7 source_urls_present
verapamil po spec_pk1_oral.yml 3 21 7 source_urls_present

値単位の確認一覧

Drug Record Parameter Fixture value Reference value Basis Source Review status
abciximab model_parameter model.theta.CL 10.98 10.98 L/h derived_from_reported source_2 checked
abciximab model_parameter model.theta.V 100.8 100.8 L derived_from_reported source_6 checked
abciximab pk_parameter CL_abs_L_per_h_at_70kg 10.98 L/h 10.98 L/h derived_from_reported source_2 checked
abciximab pk_parameter CL_systemic_L_per_h_at_70kg 10.98 L/h   derived_from_reported - derived_from_pk_yml_source_fields
abciximab pk_parameter V_abs_L_at_70kg 100.8 L 100.8 L derived_from_reported source_6 checked
abciximab pk_parameter V_systemic_L_at_70kg 100.8 L   derived_from_reported - derived_from_pk_yml_source_fields
abciximab pk_parameter bioavailability 1.0 fraction   - - source_url_present_not_parameter_mapped
abciximab pk_parameter clearance 10.98 L/h 10.98 L/h derived_from_reported source_2 checked
abciximab pk_parameter ke_1_per_h 0.10892857142857143 1/h   derived_from_reported - derived_from_pk_yml_source_fields
abciximab pk_parameter t_half_h 0.4166666666666667 h 0.4166666666666667 h derived_from_reported source_5 checked
abciximab pk_parameter volume 1.44 L/kg 1.44 L/kg derived_from_reported source_6 checked
abciximab target targets.auc 9107.468123861567 ng*h/mL   dose_over_cl - derived_target
abciximab target targets.t_half 0.4166666666666667 h   unknown_needs_review - target_without_source_mapping
aciclovir model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
aciclovir model_parameter model.theta.CL 19.62 19.62 L/h derived_from_reported source_4 checked
aciclovir model_parameter model.theta.F1 0.1 fraction   fixture_policy - fixture_policy_apparent_parameters
aciclovir model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
aciclovir model_parameter model.theta.V 46.666666666666664 46.666666666666664 L derived_from_reported source_5 checked
aciclovir pk_parameter CL_abs_L_per_h_at_70kg 19.62 L/h 19.62 L/h label_reported source_4 checked
aciclovir pk_parameter CL_systemic_L_per_h_at_70kg 19.62 L/h   derived_from_reported - derived_from_pk_yml_source_fields
aciclovir pk_parameter V_abs_L_at_70kg 46.666666666666664 L 46.666666666666664 L literature_reported source_5 checked
aciclovir pk_parameter V_systemic_L_at_70kg 46.666666666666664 L   derived_from_reported - derived_from_pk_yml_source_fields
aciclovir pk_parameter bioavailability 0.1 fraction   - - source_url_present_not_parameter_mapped
aciclovir pk_parameter clearance 19.62 L/h 19.62 L/h label_reported source_4 checked
aciclovir pk_parameter ke_1_per_h 0.4204285714285715 1/h   derived_from_reported - derived_from_pk_yml_source_fields
aciclovir pk_parameter t_half_h 2.5 h 2.5 h derived_from_reported source_1 checked
aciclovir pk_parameter volume 0.6666666666666666 L/kg 0.6666666666666666 L/kg literature_reported source_5 checked
aciclovir target targets.auc 509.683995922528 ng*h/mL   f_dose_over_cl - target_without_source_mapping
aciclovir target targets.t_half 2.5 h   unknown_needs_review - target_without_source_mapping
albuterol model_parameter model.theta.CL 28.8 28.8 L/h derived_from_reported source_1 checked
albuterol model_parameter model.theta.V 160.38152230554428 160.38152230554428 L derived_from_reported source_1 checked
albuterol pk_parameter CL_abs_L_per_h_at_70kg 28.8 L/h 28.8 L/h derived_from_reported source_1 checked
albuterol pk_parameter CL_systemic_L_per_h_at_70kg 28.8 L/h   derived_from_reported - derived_from_pk_yml_source_fields
albuterol pk_parameter V_abs_L_at_70kg 160.38152230554428 L 160.38152230554428 L fixture_derived source_1 checked
albuterol pk_parameter V_systemic_L_at_70kg 160.38152230554428 L   derived_from_reported - derived_from_pk_yml_source_fields
albuterol pk_parameter bioavailability 1.0 fraction   - - source_url_present_not_parameter_mapped
albuterol pk_parameter clearance 28.8 L/h 28.8 L/h derived_from_reported source_1 checked
albuterol pk_parameter ke_1_per_h 0.179571808435219 1/h   derived_from_reported - derived_from_pk_yml_source_fields
albuterol pk_parameter t_half_h 3.86 h 3.86 h literature_reported source_1 checked
albuterol pk_parameter volume 160.38152230554428 L 160.38152230554428 L fixture_derived source_1 checked
albuterol target targets.auc 34.72222222222222 ng*h/mL   dose_over_cl - derived_target
albuterol target targets.t_half 3.86 h   unknown_needs_review - target_without_source_mapping
alfentanil model_parameter model.theta.CL 21.0 21.0 L/h derived_from_reported source_1 checked
alfentanil model_parameter model.theta.V 70.0 70.0 L derived_from_reported source_1 checked
alfentanil pk_parameter CL_abs_L_per_h_at_70kg 21.0 L/h 21.0 L/h derived_from_reported source_1 checked
alfentanil pk_parameter CL_systemic_L_per_h_at_70kg 21.0 L/h   derived_from_reported - derived_from_pk_yml_source_fields
alfentanil pk_parameter V_abs_L_at_70kg 70.0 L 70.0 L derived_from_reported source_1 checked
alfentanil pk_parameter V_systemic_L_at_70kg 70.0 L   derived_from_reported - derived_from_pk_yml_source_fields
alfentanil pk_parameter bioavailability 1.0 fraction   - - source_url_present_not_parameter_mapped
alfentanil pk_parameter clearance 0.3 L/h/kg 0.3 L/h/kg derived_from_reported source_1 checked
alfentanil pk_parameter ke_1_per_h 0.3 1/h   derived_from_reported - derived_from_pk_yml_source_fields
alfentanil pk_parameter t_half_h 1.675 h 1.675 h derived_from_reported source_1 checked
alfentanil pk_parameter volume 1.0 L/kg 1.0 L/kg derived_from_reported source_1 checked
alfentanil target targets.auc 4761.9047619047615 ng*h/mL   dose_over_cl - derived_target
alfentanil target targets.t_half 1.675 h   unknown_needs_review - target_without_source_mapping
alprazolam model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
alprazolam model_parameter model.theta.CL 6.3 6.3 L/h derived_from_reported source_1 checked
alprazolam model_parameter model.theta.F1 1.0 fraction   fixture_policy - fixture_policy_apparent_parameters
alprazolam model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
alprazolam model_parameter model.theta.V 91.0 91.0 L derived_from_reported source_1 checked
alprazolam pk_parameter CL_abs_L_per_h_at_70kg 6.3 L/h 6.3 L/h derived_from_reported source_1 checked
alprazolam pk_parameter CL_systemic_L_per_h_at_70kg 5.67 L/h   derived_from_reported - derived_from_pk_yml_source_fields
alprazolam pk_parameter V_abs_L_at_70kg 91.0 L 91.0 L derived_from_reported source_1 checked
alprazolam pk_parameter V_systemic_L_at_70kg 81.9 L   derived_from_reported - derived_from_pk_yml_source_fields
alprazolam pk_parameter bioavailability 0.9 fraction   - - source_url_present_not_parameter_mapped
alprazolam pk_parameter clearance 0.09 L/h/kg 0.09 L/h/kg derived_from_reported source_1 checked
alprazolam pk_parameter ke_1_per_h 0.06923076923076923 1/h   derived_from_reported - derived_from_pk_yml_source_fields
alprazolam pk_parameter t_half_h 12.5 h 12.5 h derived_from_reported source_1 checked
alprazolam pk_parameter volume 1.3 L/kg 1.3 L/kg derived_from_reported source_1 checked
alprazolam target targets.auc 15873.015873015873 ng*h/mL   dose_over_cl - derived_target
alprazolam target targets.t_half 12.5 h   unknown_needs_review - target_without_source_mapping
amikacin model_parameter model.theta.CL 6.0 6.0 L/h derived_from_reported source_1 checked
amikacin model_parameter model.theta.V 24.0 24.0 L derived_from_reported source_1 checked
amikacin pk_parameter CL_abs_L_per_h_at_70kg 6.0 L/h 6.0 L/h label_reported source_1 checked
amikacin pk_parameter CL_systemic_L_per_h_at_70kg 6.0 L/h   derived_from_reported - derived_from_pk_yml_source_fields
amikacin pk_parameter V_abs_L_at_70kg 24.0 L 24.0 L label_reported source_1 checked
amikacin pk_parameter V_systemic_L_at_70kg 24.0 L   derived_from_reported - derived_from_pk_yml_source_fields
amikacin pk_parameter bioavailability 1.0 fraction   - - source_url_present_not_parameter_mapped
amikacin pk_parameter clearance 6.0 L/h 6.0 L/h label_reported source_1 checked
amikacin pk_parameter ke_1_per_h 0.25 1/h   derived_from_reported - derived_from_pk_yml_source_fields
amikacin pk_parameter t_half_h 2.0 h 2.0 h derived_from_reported source_1 checked
amikacin pk_parameter volume 24.0 L 24.0 L label_reported source_1 checked
amikacin target targets.auc 16666.666666666668 ng*h/mL   dose_over_cl - derived_target
amikacin target targets.t_half 2.0 h   unknown_needs_review - target_without_source_mapping
apixaban model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
apixaban model_parameter model.theta.CL 3.3 3.3 L/h derived_from_reported source_1 checked
apixaban model_parameter model.theta.F1 1.0 fraction   fixture_policy - fixture_policy_apparent_parameters
apixaban model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
apixaban model_parameter model.theta.V 57.130723619202946 57.130723619202946 L derived_from_reported source_1 checked
apixaban pk_parameter CL_abs_L_per_h_at_70kg 3.3 L/h 3.3 L/h label_reported source_1 checked
apixaban pk_parameter CL_systemic_L_per_h_at_70kg 1.65 L/h   derived_from_reported - derived_from_pk_yml_source_fields
apixaban pk_parameter V_abs_L_at_70kg 57.130723619202946 L 57.130723619202946 L fixture_derived source_1 checked
apixaban pk_parameter V_systemic_L_at_70kg 28.565361809601473 L   derived_from_reported - derived_from_pk_yml_source_fields
apixaban pk_parameter bioavailability 0.5 fraction   - - source_url_present_not_parameter_mapped
apixaban pk_parameter clearance 3.3 L/h 3.3 L/h label_reported source_1 checked
apixaban pk_parameter ke_1_per_h 0.05776226504666211 1/h   derived_from_reported - derived_from_pk_yml_source_fields
apixaban pk_parameter t_half_h 12.0 h 12.0 h label_reported source_1 checked
apixaban pk_parameter volume 57.130723619202946 L 57.130723619202946 L fixture_derived source_1 checked
apixaban target targets.auc 3030.3030303030305 ng*h/mL   dose_over_cl - derived_target
apixaban target targets.t_half 12.0 h   unknown_needs_review - target_without_source_mapping
atazanavir model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
atazanavir model_parameter model.theta.CL 12.9 12.9 L/h derived_from_reported source_2 checked
atazanavir model_parameter model.theta.F1 1.0 fraction   fixture_policy - fixture_policy_apparent_parameters
atazanavir model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
atazanavir model_parameter model.theta.V 88.3 88.3 L derived_from_reported source_2 checked
atazanavir pk_parameter CL_abs_L_per_h_at_70kg 12.9 L/h 12.9 L/h literature_reported source_2 checked
atazanavir pk_parameter V_abs_L_at_70kg 88.3 L 88.3 L literature_reported source_2 checked
atazanavir pk_parameter clearance 12.9 L/h 12.9 L/h literature_reported source_2 checked
atazanavir pk_parameter ke_1_per_h 0.14609286523216308 1/h   derived_from_reported - derived_from_pk_yml_source_fields
atazanavir pk_parameter t_half_h 4.6 h 4.6 h literature_reported source_2 checked
atazanavir pk_parameter volume 88.3 L 88.3 L literature_reported source_2 checked
atazanavir target targets.auc 7751.937984496124 ng*h/mL   dose_over_cl - derived_target
atazanavir target targets.t_half 4.6 h   unknown_needs_review - target_without_source_mapping
buprenorphine model_parameter model.theta.CL 54.0 54.0 L/h derived_from_reported source_2 checked
buprenorphine model_parameter model.theta.V 806.0 806.0 L derived_from_reported source_2 checked
buprenorphine pk_parameter CL_abs_L_per_h_at_70kg 54.0 L/h 54.0 L/h literature_reported source_2 checked
buprenorphine pk_parameter CL_systemic_L_per_h_at_70kg 54.0 L/h   derived_from_reported - derived_from_pk_yml_source_fields
buprenorphine pk_parameter V_abs_L_at_70kg 806.0 L 806.0 L literature_reported source_2 checked
buprenorphine pk_parameter V_systemic_L_at_70kg 806.0 L   derived_from_reported - derived_from_pk_yml_source_fields
buprenorphine pk_parameter bioavailability 1.0 fraction   - - source_url_present_not_parameter_mapped
buprenorphine pk_parameter clearance 54.0 L/h 54.0 L/h literature_reported source_2 checked
buprenorphine pk_parameter ke_1_per_h 0.06699751861042183 1/h   derived_from_reported - derived_from_pk_yml_source_fields
buprenorphine pk_parameter t_half_h 10.345863472802147 h 10.345863472802147 h derived_from_reported source_2 checked
buprenorphine pk_parameter volume 806.0 L 806.0 L literature_reported source_2 checked
buprenorphine target targets.auc 5.555555555555555 ng*h/mL   dose_over_cl - derived_target
buprenorphine target targets.t_half 10.345863472802147 h   unknown_needs_review - target_without_source_mapping
carbamazepine model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
carbamazepine model_parameter model.theta.CL 4.8 4.8 L/h derived_from_reported source_1 checked
carbamazepine model_parameter model.theta.F1 1.0 fraction   fixture_policy - fixture_policy_apparent_parameters
carbamazepine model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
carbamazepine model_parameter model.theta.V 100.41157484587185 100.41157484587185 L derived_from_reported source_1 checked
carbamazepine pk_parameter CL_abs_L_per_h_at_70kg 4.8 L/h 4.8 L/h label_reported source_1 checked
carbamazepine pk_parameter CL_systemic_L_per_h_at_70kg 4.8 L/h   derived_from_reported - derived_from_pk_yml_source_fields
carbamazepine pk_parameter V_abs_L_at_70kg 100.41157484587185 L 100.41157484587185 L derived_from_reported source_1 checked
carbamazepine pk_parameter V_systemic_L_at_70kg 100.41157484587185 L   derived_from_reported - derived_from_pk_yml_source_fields
carbamazepine pk_parameter bioavailability 1.0 fraction   - - source_url_present_not_parameter_mapped
carbamazepine pk_parameter clearance 4.8 L/h 4.8 L/h label_reported source_1 checked
carbamazepine pk_parameter ke_1_per_h 0.04780325383172036 1/h   derived_from_reported - derived_from_pk_yml_source_fields
carbamazepine pk_parameter t_half_h 14.5 h 14.5 h derived_from_reported source_1 checked
carbamazepine pk_parameter volume 100.41157484587185 L 100.41157484587185 L derived_from_reported source_1 checked
carbamazepine target targets.auc 41666.66666666667 ng*h/mL   dose_over_cl - derived_target
carbamazepine target targets.t_half 14.5 h   unknown_needs_review - target_without_source_mapping
cda1 model_parameter model.theta.CL 0.00588 0.00588 L/h derived_from_reported source_2 checked
cda1 model_parameter model.theta.V 4.9 4.9 L derived_from_reported source_2 checked
cda1 pk_parameter CL_abs_L_per_h_at_70kg 0.00588 L/h 0.00588 L/h literature_reported source_2 checked
cda1 pk_parameter CL_systemic_L_per_h_at_70kg 0.00588 L/h   derived_from_reported - derived_from_pk_yml_source_fields
cda1 pk_parameter V_abs_L_at_70kg 4.9 L 4.9 L literature_reported source_2 checked
cda1 pk_parameter V_systemic_L_at_70kg 4.9 L   derived_from_reported - derived_from_pk_yml_source_fields
cda1 pk_parameter bioavailability 1.0 fraction   - - source_url_present_not_parameter_mapped
cda1 pk_parameter clearance 8.4e-05 L/h/kg 8.4e-05 L/h/kg literature_reported source_2 checked
cda1 pk_parameter ke_1_per_h 0.0012 1/h   derived_from_reported - derived_from_pk_yml_source_fields
cda1 pk_parameter t_half_h 685.2 h 685.2 h derived_from_reported source_1 checked
cda1 pk_parameter volume 0.07 L/kg 0.07 L/kg literature_reported source_2 checked
cda1 target targets.auc 17006802.721088436 ng*h/mL   dose_over_cl - derived_target
cda1 target targets.t_half 685.2 h   unknown_needs_review - target_without_source_mapping
cimetidine model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
cimetidine model_parameter model.theta.CL 29.7 29.7 L/h derived_from_reported source_2 checked
cimetidine model_parameter model.theta.F1 0.6 fraction   fixture_policy - fixture_policy_apparent_parameters
cimetidine model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
cimetidine model_parameter model.theta.V 56.0 56.0 L derived_from_reported source_2 checked
cimetidine pk_parameter CL_abs_L_per_h_at_70kg 29.7 L/h 29.7 L/h literature_reported source_2 checked
cimetidine pk_parameter CL_systemic_L_per_h_at_70kg 29.7 L/h   derived_from_reported - derived_from_pk_yml_source_fields
cimetidine pk_parameter V_abs_L_at_70kg 56.0 L 56.0 L literature_reported source_2 checked
cimetidine pk_parameter V_systemic_L_at_70kg 56.0 L   derived_from_reported - derived_from_pk_yml_source_fields
cimetidine pk_parameter bioavailability 0.6 fraction   - - source_url_present_not_parameter_mapped
cimetidine pk_parameter clearance 29.7 L/h 29.7 L/h literature_reported source_2 checked
cimetidine pk_parameter ke_1_per_h 0.5303571428571429 1/h   derived_from_reported - derived_from_pk_yml_source_fields
cimetidine pk_parameter t_half_h 2.0 h 2.0 h label_reported source_1 checked
cimetidine pk_parameter volume 0.8 L/kg 0.8 L/kg literature_reported source_2 checked
cimetidine target targets.auc 2020.2020202020203 ng*h/mL   f_dose_over_cl - target_without_source_mapping
cimetidine target targets.t_half 2.0 h   unknown_needs_review - target_without_source_mapping
clarithromycin model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
clarithromycin model_parameter model.theta.CL 58.1 58.1 L/h derived_from_reported source_2 checked
clarithromycin model_parameter model.theta.F1 1.0 fraction   fixture_policy - fixture_policy_apparent_parameters
clarithromycin model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
clarithromycin model_parameter model.theta.V 172.0 172.0 L derived_from_reported source_3 checked
clarithromycin pk_parameter CL_abs_L_per_h_at_70kg 58.1 L/h 58.1 L/h derived_from_reported source_2 checked
clarithromycin pk_parameter CL_systemic_L_per_h_at_70kg 30.5025 L/h   derived_from_reported - derived_from_pk_yml_source_fields
clarithromycin pk_parameter V_abs_L_at_70kg 172.0 L 172.0 L derived_from_reported source_3 checked
clarithromycin pk_parameter V_systemic_L_at_70kg 90.3 L   derived_from_reported - derived_from_pk_yml_source_fields
clarithromycin pk_parameter bioavailability 0.525 fraction   - - source_url_present_not_parameter_mapped
clarithromycin pk_parameter clearance 58.1 L/h 58.1 L/h derived_from_reported source_2 checked
clarithromycin pk_parameter ke_1_per_h 0.3377906976744186 1/h   derived_from_reported - derived_from_pk_yml_source_fields
clarithromycin pk_parameter t_half_h 5.0 h 5.0 h derived_from_reported source_1 checked
clarithromycin pk_parameter volume 172.0 L 172.0 L derived_from_reported source_3 checked
clarithromycin target targets.auc 1721.170395869191 ng*h/mL   dose_over_cl - derived_target
clarithromycin target targets.t_half 5.0 h   unknown_needs_review - target_without_source_mapping
dapagliflozin model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
dapagliflozin model_parameter model.theta.CL 12.42 12.42 L/h derived_from_reported source_1 checked
dapagliflozin model_parameter model.theta.F1 0.78 fraction   fixture_policy - fixture_policy_apparent_parameters
dapagliflozin model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
dapagliflozin model_parameter model.theta.V 118.0 118.0 L derived_from_reported source_1 checked
dapagliflozin pk_parameter CL_abs_L_per_h_at_70kg 12.42 L/h 12.42 L/h literature_reported source_1 checked
dapagliflozin pk_parameter CL_systemic_L_per_h_at_70kg 12.42 L/h   derived_from_reported - derived_from_pk_yml_source_fields
dapagliflozin pk_parameter V_abs_L_at_70kg 118.0 L 118.0 L literature_reported source_1 checked
dapagliflozin pk_parameter V_systemic_L_at_70kg 118.0 L   derived_from_reported - derived_from_pk_yml_source_fields
dapagliflozin pk_parameter bioavailability 0.78 fraction   - - source_url_present_not_parameter_mapped
dapagliflozin pk_parameter clearance 12.42 L/h 12.42 L/h literature_reported source_1 checked
dapagliflozin pk_parameter ke_1_per_h 0.1052542372881356 1/h   derived_from_reported - derived_from_pk_yml_source_fields
dapagliflozin pk_parameter t_half_h 12.9 h 12.9 h label_reported source_1 checked
dapagliflozin pk_parameter volume 118.0 L 118.0 L literature_reported source_1 checked
dapagliflozin target targets.auc 628.0193236714975 ng*h/mL   f_dose_over_cl - target_without_source_mapping
dapagliflozin target targets.t_half 12.9 h   unknown_needs_review - target_without_source_mapping
efavirenz model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
efavirenz model_parameter model.theta.CL 13.9 13.9 L/h derived_from_reported source_2 checked
efavirenz model_parameter model.theta.F1 1.0 fraction   fixture_policy - fixture_policy_apparent_parameters
efavirenz model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
efavirenz model_parameter model.theta.V 1163.1007419646824 1163.1007419646824 L derived_from_reported source_2 checked
efavirenz pk_parameter CL_abs_L_per_h_at_70kg 13.9 L/h 13.9 L/h literature_reported source_2 checked
efavirenz pk_parameter V_abs_L_at_70kg 1163.1007419646824 L 1163.1007419646824 L derived_from_reported source_2 checked
efavirenz pk_parameter clearance 13.9 L/h 13.9 L/h literature_reported source_2 checked
efavirenz pk_parameter ke_1_per_h 0.01195081345793009 1/h   derived_from_reported - derived_from_pk_yml_source_fields
efavirenz pk_parameter t_half_h 58.0 h 58.0 h derived_from_reported source_1 checked
efavirenz pk_parameter volume 1163.1007419646824 L 1163.1007419646824 L derived_from_reported source_2 checked
efavirenz target targets.auc 7194.244604316546 ng*h/mL   dose_over_cl - derived_target
efavirenz target targets.t_half 58.0 h   unknown_needs_review - target_without_source_mapping
erythromycin model_parameter model.theta.CL 37.1 37.1 L/h derived_from_reported source_1 checked
erythromycin model_parameter model.theta.V 123.10516783905524 123.10516783905524 L derived_from_reported source_1 checked
erythromycin pk_parameter CL_abs_L_per_h_at_70kg 37.1 L/h 37.1 L/h literature_reported source_1 checked
erythromycin pk_parameter CL_systemic_L_per_h_at_70kg 37.1 L/h   derived_from_reported - derived_from_pk_yml_source_fields
erythromycin pk_parameter V_abs_L_at_70kg 123.10516783905524 L 123.10516783905524 L fixture_derived source_1 checked
erythromycin pk_parameter V_systemic_L_at_70kg 123.10516783905524 L   derived_from_reported - derived_from_pk_yml_source_fields
erythromycin pk_parameter bioavailability 1.0 fraction   - - source_url_present_not_parameter_mapped
erythromycin pk_parameter clearance 0.53 L/h/kg 0.53 L/h/kg literature_reported source_1 checked
erythromycin pk_parameter ke_1_per_h 0.3013683393738893 1/h   derived_from_reported - derived_from_pk_yml_source_fields
erythromycin pk_parameter t_half_h 2.3 h 2.3 h literature_reported source_1 checked
erythromycin pk_parameter volume 1.7586452548436462 L/kg 1.7586452548436462 L/kg fixture_derived source_1 checked
erythromycin target targets.auc 3369.272237196765 ng*h/mL   dose_over_cl - derived_target
erythromycin target targets.t_half 2.3 h   unknown_needs_review - target_without_source_mapping
ethinylestradiol model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
ethinylestradiol model_parameter model.theta.CL 25.7 25.7 L/h derived_from_reported source_1 checked
ethinylestradiol model_parameter model.theta.F1 1.0 fraction   fixture_policy - fixture_policy_apparent_parameters
ethinylestradiol model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
ethinylestradiol model_parameter model.theta.V 632.1673264919305 632.1673264919305 L derived_from_reported source_1 checked
ethinylestradiol pk_parameter CL_abs_L_per_h_at_70kg 25.7 L/h 25.7 L/h literature_reported source_1 checked
ethinylestradiol pk_parameter CL_systemic_L_per_h_at_70kg 11.051 L/h   derived_from_reported - derived_from_pk_yml_source_fields
ethinylestradiol pk_parameter V_abs_L_at_70kg 632.1673264919305 L 632.1673264919305 L fixture_derived source_1 checked
ethinylestradiol pk_parameter V_systemic_L_at_70kg 271.8319503915301 L   derived_from_reported - derived_from_pk_yml_source_fields
ethinylestradiol pk_parameter bioavailability 0.43 fraction   - - source_url_present_not_parameter_mapped
ethinylestradiol pk_parameter clearance 25.7 L/h 25.7 L/h literature_reported source_1 checked
ethinylestradiol pk_parameter ke_1_per_h 0.04065379358122846 1/h   derived_from_reported - derived_from_pk_yml_source_fields
ethinylestradiol pk_parameter t_half_h 17.05 h 17.05 h derived_from_reported source_1 checked
ethinylestradiol pk_parameter volume 632.1673264919305 L 632.1673264919305 L fixture_derived source_1 checked
ethinylestradiol target targets.auc 3891.0505836575876 ng*h/mL   dose_over_cl - derived_target
ethinylestradiol target targets.t_half 17.05 h   unknown_needs_review - target_without_source_mapping
felodipine model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
felodipine model_parameter model.theta.CL 90.0 90.0 L/h derived_from_reported source_2 checked
felodipine model_parameter model.theta.F1 0.15 fraction   fixture_policy - fixture_policy_apparent_parameters
felodipine model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
felodipine model_parameter model.theta.V 700.0 700.0 L derived_from_reported source_2 checked
felodipine pk_parameter CL_abs_L_per_h_at_70kg 90.0 L/h 90.0 L/h derived_from_reported source_2 checked
felodipine pk_parameter CL_systemic_L_per_h_at_70kg 90.0 L/h   derived_from_reported - derived_from_pk_yml_source_fields
felodipine pk_parameter V_abs_L_at_70kg 700.0 L 700.0 L derived_from_reported source_2 checked
felodipine pk_parameter V_systemic_L_at_70kg 700.0 L   derived_from_reported - derived_from_pk_yml_source_fields
felodipine pk_parameter bioavailability 0.15 fraction   - - source_url_present_not_parameter_mapped
felodipine pk_parameter clearance 90.0 L/h 90.0 L/h derived_from_reported source_2 checked
felodipine pk_parameter ke_1_per_h 0.12857142857142856 1/h   derived_from_reported - derived_from_pk_yml_source_fields
felodipine pk_parameter t_half_h 24.5 h 24.5 h derived_from_reported source_2 checked
felodipine pk_parameter volume 10.0 L/kg 10.0 L/kg derived_from_reported source_2 checked
felodipine target targets.auc 166.66666666666666 ng*h/mL   f_dose_over_cl - target_without_source_mapping
felodipine target targets.t_half 24.5 h   unknown_needs_review - target_without_source_mapping
fluconazole model_parameter model.theta.CL 0.966 0.966 L/h derived_from_reported source_1 checked
fluconazole model_parameter model.theta.V 41.80930228496216 41.80930228496216 L derived_from_reported source_1 checked
fluconazole pk_parameter CL_abs_L_per_h_at_70kg 0.966 L/h 0.966 L/h derived_from_reported source_1 checked
fluconazole pk_parameter CL_systemic_L_per_h_at_70kg 0.966 L/h   derived_from_reported - derived_from_pk_yml_source_fields
fluconazole pk_parameter V_abs_L_at_70kg 41.80930228496216 L 41.80930228496216 L fixture_derived source_1 checked
fluconazole pk_parameter V_systemic_L_at_70kg 41.80930228496216 L   derived_from_reported - derived_from_pk_yml_source_fields
fluconazole pk_parameter bioavailability 1.0 fraction   - - source_url_present_not_parameter_mapped
fluconazole pk_parameter clearance 0.0138 L/h/kg 0.0138 L/h/kg derived_from_reported source_1 checked
fluconazole pk_parameter ke_1_per_h 0.023104906018664845 1/h   derived_from_reported - derived_from_pk_yml_source_fields
fluconazole pk_parameter t_half_h 30.0 h 30.0 h label_reported source_1 checked
fluconazole pk_parameter volume 0.5972757469280309 L/kg 0.5972757469280309 L/kg fixture_derived source_1 checked
fluconazole target targets.auc 207039.33747412008 ng*h/mL   dose_over_cl - derived_target
fluconazole target targets.t_half 30.0 h   unknown_needs_review - target_without_source_mapping
fluvoxamine model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
fluvoxamine model_parameter model.theta.CL 65.56797653945428 65.56797653945428 L/h derived_from_reported source_1 checked
fluvoxamine model_parameter model.theta.F1 1.0 fraction   fixture_policy - fixture_policy_apparent_parameters
fluvoxamine model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
fluvoxamine model_parameter model.theta.V 1750.0 1750.0 L derived_from_reported source_1 checked
fluvoxamine pk_parameter CL_abs_L_per_h_at_70kg 65.56797653945428 L/h 65.56797653945428 L/h derived_from_reported source_1 checked
fluvoxamine pk_parameter CL_systemic_L_per_h_at_70kg 34.75102756591077 L/h   derived_from_reported - derived_from_pk_yml_source_fields
fluvoxamine pk_parameter V_abs_L_at_70kg 1750.0 L 1750.0 L literature_reported source_1 checked
fluvoxamine pk_parameter V_systemic_L_at_70kg 927.5 L   derived_from_reported - derived_from_pk_yml_source_fields
fluvoxamine pk_parameter bioavailability 0.53 fraction   - - source_url_present_not_parameter_mapped
fluvoxamine pk_parameter clearance 65.56797653945428 L/h 65.56797653945428 L/h derived_from_reported source_1 checked
fluvoxamine pk_parameter ke_1_per_h 0.037467415165402446 1/h   derived_from_reported - derived_from_pk_yml_source_fields
fluvoxamine pk_parameter t_half_h 18.5 h 18.5 h derived_from_reported source_1 checked
fluvoxamine pk_parameter volume 25.0 L/kg 25.0 L/kg literature_reported source_1 checked
fluvoxamine target targets.auc 1525.1347575111902 ng*h/mL   dose_over_cl - derived_target
fluvoxamine target targets.t_half 18.5 h   unknown_needs_review - target_without_source_mapping
inulin model_parameter model.theta.CL 5.61 5.61 L/h derived_from_reported source_3 checked
inulin model_parameter model.theta.V 13.0 13.0 L derived_from_reported source_3 checked
inulin pk_parameter CL_abs_L_per_h_at_70kg 5.61 L/h 5.61 L/h literature_reported source_3 checked
inulin pk_parameter CL_systemic_L_per_h_at_70kg 5.61 L/h   derived_from_reported - derived_from_pk_yml_source_fields
inulin pk_parameter V_abs_L_at_70kg 13.0 L 13.0 L literature_reported source_3 checked
inulin pk_parameter V_systemic_L_at_70kg 13.0 L   derived_from_reported - derived_from_pk_yml_source_fields
inulin pk_parameter bioavailability 1.0 fraction   - - source_url_present_not_parameter_mapped
inulin pk_parameter clearance 5.61 L/h 5.61 L/h literature_reported source_3 checked
inulin pk_parameter ke_1_per_h 0.43153846153846154 1/h   derived_from_reported - derived_from_pk_yml_source_fields
inulin pk_parameter t_half_h 1.6062234130622617 h 1.6062234130622617 h derived_from_reported source_3 checked
inulin pk_parameter volume 13.0 L 13.0 L literature_reported source_3 checked
inulin target targets.auc 17825.311942959 ng*h/mL   dose_over_cl - derived_target
inulin target targets.t_half 1.6062234130622617 h   unknown_needs_review - target_without_source_mapping
itraconazole model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
itraconazole model_parameter model.theta.CL 16.68 16.68 L/h derived_from_reported source_1 checked
itraconazole model_parameter model.theta.F1 0.55 fraction   fixture_policy - fixture_policy_apparent_parameters
itraconazole model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
itraconazole model_parameter model.theta.V 700.0 700.0 L derived_from_reported source_1 checked
itraconazole pk_parameter CL_abs_L_per_h_at_70kg 16.68 L/h 16.68 L/h label_reported source_1 checked
itraconazole pk_parameter CL_systemic_L_per_h_at_70kg 16.68 L/h   derived_from_reported - derived_from_pk_yml_source_fields
itraconazole pk_parameter V_abs_L_at_70kg 700.0 L 700.0 L derived_from_reported source_1 checked
itraconazole pk_parameter V_systemic_L_at_70kg 700.0 L   derived_from_reported - derived_from_pk_yml_source_fields
itraconazole pk_parameter bioavailability 0.55 fraction   - - source_url_present_not_parameter_mapped
itraconazole pk_parameter clearance 16.68 L/h 16.68 L/h label_reported source_1 checked
itraconazole pk_parameter ke_1_per_h 0.023828571428571428 1/h   derived_from_reported - derived_from_pk_yml_source_fields
itraconazole pk_parameter t_half_h 22.0 h 22.0 h derived_from_reported source_1 checked
itraconazole pk_parameter volume 700.0 L 700.0 L derived_from_reported source_1 checked
itraconazole target targets.auc 3297.3621103117507 ng*h/mL   f_dose_over_cl - target_without_source_mapping
itraconazole target targets.t_half 22.0 h   unknown_needs_review - target_without_source_mapping
mefenamic_acid model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
mefenamic_acid model_parameter model.theta.CL 21.13 21.13 L/h derived_from_reported source_1 checked
mefenamic_acid model_parameter model.theta.F1 1.0 fraction   fixture_policy - fixture_policy_apparent_parameters
mefenamic_acid model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
mefenamic_acid model_parameter model.theta.V 74.2 74.2 L derived_from_reported source_1 checked
mefenamic_acid pk_parameter CL_abs_L_per_h_at_70kg 21.13 L/h 21.13 L/h literature_reported source_1 checked
mefenamic_acid pk_parameter V_abs_L_at_70kg 74.2 L 74.2 L literature_reported source_1 checked
mefenamic_acid pk_parameter clearance 21.13 L/h 21.13 L/h literature_reported source_1 checked
mefenamic_acid pk_parameter ke_1_per_h 0.2847708894878706 1/h   derived_from_reported - derived_from_pk_yml_source_fields
mefenamic_acid pk_parameter t_half_h 3.0 h 3.0 h derived_from_reported source_1 checked
mefenamic_acid pk_parameter volume 1.06 L/kg 1.06 L/kg literature_reported source_1 checked
mefenamic_acid target targets.auc 4732.60766682442 ng*h/mL   dose_over_cl - derived_target
mefenamic_acid target targets.t_half 3.0 h   unknown_needs_review - target_without_source_mapping
metoprolol model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
metoprolol model_parameter model.theta.CL 48.0 48.0 L/h derived_from_reported source_2 checked
metoprolol model_parameter model.theta.F1 0.5 fraction   fixture_policy - fixture_policy_apparent_parameters
metoprolol model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
metoprolol model_parameter model.theta.V 346.2468098133512 346.2468098133512 L derived_from_reported source_1 checked
metoprolol pk_parameter CL_abs_L_per_h_at_70kg 48.0 L/h 48.0 L/h literature_reported source_2 checked
metoprolol pk_parameter CL_systemic_L_per_h_at_70kg 48.0 L/h   derived_from_reported - derived_from_pk_yml_source_fields
metoprolol pk_parameter V_abs_L_at_70kg 346.2468098133512 L 346.2468098133512 L derived_from_reported source_1 checked
metoprolol pk_parameter V_systemic_L_at_70kg 346.2468098133512 L   derived_from_reported - derived_from_pk_yml_source_fields
metoprolol pk_parameter bioavailability 0.5 fraction   - - source_url_present_not_parameter_mapped
metoprolol pk_parameter clearance 48.0 L/h 48.0 L/h literature_reported source_2 checked
metoprolol pk_parameter ke_1_per_h 0.13862943611198908 1/h   derived_from_reported - derived_from_pk_yml_source_fields
metoprolol pk_parameter t_half_h 5.0 h 5.0 h derived_from_reported source_1 checked
metoprolol pk_parameter volume 346.2468098133512 L 346.2468098133512 L derived_from_reported source_1 checked
metoprolol target targets.auc 1041.6666666666667 ng*h/mL   f_dose_over_cl - target_without_source_mapping
metoprolol target targets.t_half 5.0 h   unknown_needs_review - target_without_source_mapping
mexiletine model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
mexiletine model_parameter model.theta.CL 30.87655622494302 30.87655622494302 L/h derived_from_reported source_1 checked
mexiletine model_parameter model.theta.F1 1.0 fraction   fixture_policy - fixture_policy_apparent_parameters
mexiletine model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
mexiletine model_parameter model.theta.V 490.0 490.0 L derived_from_reported source_1 checked
mexiletine pk_parameter CL_abs_L_per_h_at_70kg 30.87655622494302 L/h 30.87655622494302 L/h derived_from_reported source_1 checked
mexiletine pk_parameter CL_systemic_L_per_h_at_70kg 27.788900602448717 L/h   derived_from_reported - derived_from_pk_yml_source_fields
mexiletine pk_parameter V_abs_L_at_70kg 490.0 L 490.0 L derived_from_reported source_1 checked
mexiletine pk_parameter V_systemic_L_at_70kg 441.0 L   derived_from_reported - derived_from_pk_yml_source_fields
mexiletine pk_parameter bioavailability 0.9 fraction   - - source_url_present_not_parameter_mapped
mexiletine pk_parameter clearance 30.87655622494302 L/h 30.87655622494302 L/h derived_from_reported source_1 checked
mexiletine pk_parameter ke_1_per_h 0.06301338005090412 1/h   derived_from_reported - derived_from_pk_yml_source_fields
mexiletine pk_parameter t_half_h 11.0 h 11.0 h derived_from_reported source_1 checked
mexiletine pk_parameter volume 7.0 L/kg 7.0 L/kg derived_from_reported source_1 checked
mexiletine target targets.auc 3238.7031530160402 ng*h/mL   dose_over_cl - derived_target
mexiletine target targets.t_half 11.0 h   unknown_needs_review - target_without_source_mapping
moclobemide model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
moclobemide model_parameter model.theta.CL 39.4 39.4 L/h derived_from_reported source_5 checked
moclobemide model_parameter model.theta.F1 0.56 fraction   fixture_policy - fixture_policy_apparent_parameters
moclobemide model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
moclobemide model_parameter model.theta.V 84.3 84.3 L derived_from_reported source_5 checked
moclobemide pk_parameter CL_abs_L_per_h_at_70kg 39.4 L/h 39.4 L/h derived_from_reported source_5 checked
moclobemide pk_parameter CL_systemic_L_per_h_at_70kg 39.4 L/h   derived_from_reported - derived_from_pk_yml_source_fields
moclobemide pk_parameter V_abs_L_at_70kg 84.3 L 84.3 L literature_reported source_5 checked
moclobemide pk_parameter V_systemic_L_at_70kg 84.3 L   derived_from_reported - derived_from_pk_yml_source_fields
moclobemide pk_parameter bioavailability 0.56 fraction   - - source_url_present_not_parameter_mapped
moclobemide pk_parameter clearance 39.4 L/h 39.4 L/h derived_from_reported source_5 checked
moclobemide pk_parameter ke_1_per_h 0.46737841043890865 1/h   derived_from_reported - derived_from_pk_yml_source_fields
moclobemide pk_parameter t_half_h 1.6 h 1.6 h literature_reported source_5 checked
moclobemide pk_parameter volume 84.3 L 84.3 L literature_reported source_5 checked
moclobemide target targets.auc 1421.3197969543148 ng*h/mL   f_dose_over_cl - target_without_source_mapping
moclobemide target targets.t_half 1.6 h   unknown_needs_review - target_without_source_mapping
montelukast model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
montelukast model_parameter model.theta.CL 1.8479999999999999 1.8479999999999999 L/h derived_from_reported source_1 checked
montelukast model_parameter model.theta.F1 0.615 fraction   fixture_policy - fixture_policy_apparent_parameters
montelukast model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
montelukast model_parameter model.theta.V 9.7 9.7 L derived_from_reported source_1 checked
montelukast pk_parameter CL_abs_L_per_h_at_70kg 1.8479999999999999 L/h 1.8479999999999999 L/h literature_reported source_1 checked
montelukast pk_parameter CL_systemic_L_per_h_at_70kg 1.8479999999999999 L/h   derived_from_reported - derived_from_pk_yml_source_fields
montelukast pk_parameter V_abs_L_at_70kg 9.7 L 9.7 L literature_reported source_1 checked
montelukast pk_parameter V_systemic_L_at_70kg 9.7 L   derived_from_reported - derived_from_pk_yml_source_fields
montelukast pk_parameter bioavailability 0.615 fraction   - - source_url_present_not_parameter_mapped
montelukast pk_parameter clearance 1.8479999999999999 L/h 1.8479999999999999 L/h literature_reported source_1 checked
montelukast pk_parameter ke_1_per_h 0.19051546391752577 1/h   derived_from_reported - derived_from_pk_yml_source_fields
montelukast pk_parameter t_half_h 6.7 h 6.7 h literature_reported source_1 checked
montelukast pk_parameter volume 9.7 L 9.7 L literature_reported source_1 checked
montelukast target targets.auc 33279.22077922078 ng*h/mL   f_dose_over_cl - target_without_source_mapping
montelukast target targets.t_half 6.7 h   unknown_needs_review - target_without_source_mapping
motavizumab_medi_524 model_parameter model.theta.CL 0.010229166666666666 0.010229166666666666 L/h derived_from_reported source_1 checked
motavizumab_medi_524 model_parameter model.theta.V 7.35 7.35 L derived_from_reported source_1 checked
motavizumab_medi_524 pk_parameter CL_abs_L_per_h_at_70kg 0.010229166666666666 L/h 0.010229166666666666 L/h derived_from_reported source_1 checked
motavizumab_medi_524 pk_parameter CL_systemic_L_per_h_at_70kg 0.010229166666666666 L/h   derived_from_reported - derived_from_pk_yml_source_fields
motavizumab_medi_524 pk_parameter V_abs_L_at_70kg 7.35 L 7.35 L derived_from_reported source_1 checked
motavizumab_medi_524 pk_parameter V_systemic_L_at_70kg 7.35 L   derived_from_reported - derived_from_pk_yml_source_fields
motavizumab_medi_524 pk_parameter bioavailability 1.0 fraction   - - source_url_present_not_parameter_mapped
motavizumab_medi_524 pk_parameter clearance 0.010229166666666666 L/h 0.010229166666666666 L/h derived_from_reported source_1 checked
motavizumab_medi_524 pk_parameter ke_1_per_h 0.0013917233560090702 1/h   derived_from_reported - derived_from_pk_yml_source_fields
motavizumab_medi_524 pk_parameter t_half_h 636.0 h 636.0 h derived_from_reported source_1 checked
motavizumab_medi_524 pk_parameter volume 7.35 L 7.35 L derived_from_reported source_1 checked
motavizumab_medi_524 target targets.auc 9775967.413441956 ng*h/mL   dose_over_cl - derived_target
motavizumab_medi_524 target targets.t_half 636.0 h   unknown_needs_review - target_without_source_mapping
motavizumab_yte model_parameter model.theta.CL 0.0022916666666666667 0.0022916666666666667 L/h derived_from_reported source_1 checked
motavizumab_yte model_parameter model.theta.V 6.744599316155904 6.744599316155904 L derived_from_reported source_1 checked
motavizumab_yte pk_parameter CL_abs_L_per_h_at_70kg 0.0022916666666666667 L/h 0.0022916666666666667 L/h derived_from_reported source_1 checked
motavizumab_yte pk_parameter CL_systemic_L_per_h_at_70kg 0.0022916666666666667 L/h   derived_from_reported - derived_from_pk_yml_source_fields
motavizumab_yte pk_parameter V_abs_L_at_70kg 6.744599316155904 L 6.744599316155904 L fixture_derived source_1 checked
motavizumab_yte pk_parameter V_systemic_L_at_70kg 6.744599316155904 L   derived_from_reported - derived_from_pk_yml_source_fields
motavizumab_yte pk_parameter bioavailability 1.0 fraction   - - source_url_present_not_parameter_mapped
motavizumab_yte pk_parameter clearance 0.0022916666666666667 L/h 0.0022916666666666667 L/h derived_from_reported source_1 checked
motavizumab_yte pk_parameter ke_1_per_h 0.0003397780296862477 1/h   derived_from_reported - derived_from_pk_yml_source_fields
motavizumab_yte pk_parameter t_half_h 2040 h 2040 h derived_from_reported source_1 checked
motavizumab_yte pk_parameter volume 6.744599316155904 L 6.744599316155904 L fixture_derived source_1 checked
motavizumab_yte target targets.auc 43636363.63636363 ng*h/mL   dose_over_cl - derived_target
motavizumab_yte target targets.t_half 2040.0 h   unknown_needs_review - target_without_source_mapping
omeprazole model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
omeprazole model_parameter model.theta.CL 43.56 43.56 L/h derived_from_reported source_4 checked
omeprazole model_parameter model.theta.F1 0.35 fraction   fixture_policy - fixture_policy_apparent_parameters
omeprazole model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
omeprazole model_parameter model.theta.V 16.1 16.1 L derived_from_reported source_4 checked
omeprazole pk_parameter CL_abs_L_per_h_at_70kg 43.56 L/h 43.56 L/h literature_reported source_4 checked
omeprazole pk_parameter CL_systemic_L_per_h_at_70kg 43.56 L/h   derived_from_reported - derived_from_pk_yml_source_fields
omeprazole pk_parameter V_abs_L_at_70kg 16.1 L 16.1 L literature_reported source_4 checked
omeprazole pk_parameter V_systemic_L_at_70kg 16.1 L   derived_from_reported - derived_from_pk_yml_source_fields
omeprazole pk_parameter bioavailability 0.35 fraction   - - source_url_present_not_parameter_mapped
omeprazole pk_parameter clearance 43.56 L/h 43.56 L/h literature_reported source_4 checked
omeprazole pk_parameter ke_1_per_h 2.705590062111801 1/h   derived_from_reported - derived_from_pk_yml_source_fields
omeprazole pk_parameter t_half_h 0.75 h 0.75 h derived_from_reported source_2 checked
omeprazole pk_parameter volume 0.23 L/kg 0.23 L/kg literature_reported source_4 checked
omeprazole target targets.auc 803.4894398530762 ng*h/mL   f_dose_over_cl - target_without_source_mapping
omeprazole target targets.t_half 0.75 h   unknown_needs_review - target_without_source_mapping
raltegravir model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
raltegravir model_parameter model.theta.CL 60.2 60.2 L/h derived_from_reported source_1 checked
raltegravir model_parameter model.theta.F1 1.0 fraction   fixture_policy - fixture_policy_apparent_parameters
raltegravir model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
raltegravir model_parameter model.theta.V 677.4318833998217 677.4318833998217 L derived_from_reported source_1 checked
raltegravir pk_parameter CL_abs_L_per_h_at_70kg 60.2 L/h 60.2 L/h literature_reported source_1 checked
raltegravir pk_parameter CL_systemic_L_per_h_at_70kg 60.2 L/h   derived_from_reported - derived_from_pk_yml_source_fields
raltegravir pk_parameter V_abs_L_at_70kg 677.4318833998217 L 677.4318833998217 L derived_from_reported source_1 checked
raltegravir pk_parameter V_systemic_L_at_70kg 677.4318833998217 L   derived_from_reported - derived_from_pk_yml_source_fields
raltegravir pk_parameter bioavailability 1.0 fraction   - - source_url_present_not_parameter_mapped
raltegravir pk_parameter clearance 60.2 L/h 60.2 L/h literature_reported source_1 checked
raltegravir pk_parameter ke_1_per_h 0.08886502314871093 1/h   derived_from_reported - derived_from_pk_yml_source_fields
raltegravir pk_parameter t_half_h 7.8 h 7.8 h literature_reported source_2 checked
raltegravir pk_parameter volume 677.4318833998217 L 677.4318833998217 L derived_from_reported source_1 checked
raltegravir target targets.auc 6644.518272425249 ng*h/mL   dose_over_cl - derived_target
raltegravir target targets.t_half 7.8 h   unknown_needs_review - target_without_source_mapping
sildenafil model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
sildenafil model_parameter model.theta.CL 18.195113489698564 18.195113489698564 L/h derived_from_reported source_2 checked
sildenafil model_parameter model.theta.F1 1.0 fraction   fixture_policy - fixture_policy_apparent_parameters
sildenafil model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
sildenafil model_parameter model.theta.V 105.0 105.0 L derived_from_reported source_3 checked
sildenafil pk_parameter CL_abs_L_per_h_at_70kg 18.195113489698564 L/h 18.195113489698564 L/h fixture_derived source_2 checked
sildenafil pk_parameter CL_systemic_L_per_h_at_70kg 8.005849935467369 L/h   derived_from_reported - derived_from_pk_yml_source_fields
sildenafil pk_parameter V_abs_L_at_70kg 105.0 L 105.0 L literature_reported source_3 checked
sildenafil pk_parameter V_systemic_L_at_70kg 46.2 L   derived_from_reported - derived_from_pk_yml_source_fields
sildenafil pk_parameter bioavailability 0.44 fraction   - - source_url_present_not_parameter_mapped
sildenafil pk_parameter clearance 18.195113489698564 L/h 18.195113489698564 L/h fixture_derived source_2 checked
sildenafil pk_parameter ke_1_per_h 0.17328679513998632 1/h   derived_from_reported - derived_from_pk_yml_source_fields
sildenafil pk_parameter t_half_h 4.0 h 4.0 h derived_from_reported source_2 checked
sildenafil pk_parameter volume 105.0 L 105.0 L literature_reported source_3 checked
sildenafil target targets.auc 5495.981108148432 ng*h/mL   dose_over_cl - derived_target
sildenafil target targets.t_half 4.0 h   unknown_needs_review - target_without_source_mapping
sufentanil model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
sufentanil model_parameter model.theta.CL 108.0 108.0 L/h derived_from_reported source_1 checked
sufentanil model_parameter model.theta.F1 1.0 fraction   fixture_policy - fixture_policy_no_external_source
sufentanil model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
sufentanil model_parameter model.theta.V 2087.868263174508 2087.868263174508 L derived_from_reported source_1 checked
sufentanil pk_parameter CL_abs_L_per_h_at_70kg 108.0 L/h 108.0 L/h label_reported source_1 checked
sufentanil pk_parameter CL_systemic_L_per_h_at_70kg 57.24 L/h   derived_from_reported - derived_from_pk_yml_source_fields
sufentanil pk_parameter V_abs_L_at_70kg 2087.868263174508 L 2087.868263174508 L fixture_derived source_1 checked
sufentanil pk_parameter V_systemic_L_at_70kg 1106.5701794824893 L   derived_from_reported - derived_from_pk_yml_source_fields
sufentanil pk_parameter bioavailability 0.53 fraction   - - source_url_present_not_parameter_mapped
sufentanil pk_parameter clearance 108.0 L/h 108.0 L/h label_reported source_1 checked
sufentanil pk_parameter ke_1_per_h 0.05172740153432428 1/h   derived_from_reported - derived_from_pk_yml_source_fields
sufentanil pk_parameter t_half_h 13.4 h 13.4 h label_reported source_1 checked
sufentanil pk_parameter volume 2087.868263174508 L 2087.868263174508 L fixture_derived source_1 checked
sufentanil target targets.auc 0.278 ng*h/mL   literature_reported - target_without_source_mapping
sufentanil target targets.t_half 13.4 h   unknown_needs_review - target_without_source_mapping
tefibazumab model_parameter model.theta.CL 0.012 0.012 L/h derived_from_reported source_1 checked
tefibazumab model_parameter model.theta.V 7.3 7.3 L derived_from_reported source_1 checked
tefibazumab pk_parameter CL_abs_L_per_h_at_70kg 0.012 L/h 0.012 L/h literature_reported source_1 checked
tefibazumab pk_parameter CL_systemic_L_per_h_at_70kg 0.012 L/h   derived_from_reported - derived_from_pk_yml_source_fields
tefibazumab pk_parameter V_abs_L_at_70kg 7.3 L 7.3 L literature_reported source_1 checked
tefibazumab pk_parameter V_systemic_L_at_70kg 7.3 L   derived_from_reported - derived_from_pk_yml_source_fields
tefibazumab pk_parameter bioavailability 1.0 fraction   - - source_url_present_not_parameter_mapped
tefibazumab pk_parameter clearance 0.012 L/h 0.012 L/h literature_reported source_1 checked
tefibazumab pk_parameter ke_1_per_h 0.0016438356164383563 1/h   derived_from_reported - derived_from_pk_yml_source_fields
tefibazumab pk_parameter t_half_h 420.0 h 420.0 h derived_from_reported source_1 checked
tefibazumab pk_parameter volume 7.3 L 7.3 L literature_reported source_1 checked
tefibazumab target targets.auc 8333333.333333333 ng*h/mL   dose_over_cl - derived_target
tefibazumab target targets.t_half 420.0 h   unknown_needs_review - target_without_source_mapping
tizanidine model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
tizanidine model_parameter model.theta.CL 46.579490533628324 46.579490533628324 L/h derived_from_reported source_1 checked
tizanidine model_parameter model.theta.F1 0.4 fraction   fixture_policy - fixture_policy_apparent_parameters
tizanidine model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
tizanidine model_parameter model.theta.V 168.0 168.0 L derived_from_reported source_1 checked
tizanidine pk_parameter CL_abs_L_per_h_at_70kg 46.579490533628324 L/h 46.579490533628324 L/h derived_from_reported source_1 checked
tizanidine pk_parameter CL_systemic_L_per_h_at_70kg 46.579490533628324 L/h   derived_from_reported - derived_from_pk_yml_source_fields
tizanidine pk_parameter V_abs_L_at_70kg 168.0 L 168.0 L literature_reported source_1 checked
tizanidine pk_parameter V_systemic_L_at_70kg 168.0 L   derived_from_reported - derived_from_pk_yml_source_fields
tizanidine pk_parameter bioavailability 0.4 fraction   - - source_url_present_not_parameter_mapped
tizanidine pk_parameter clearance 46.579490533628324 L/h 46.579490533628324 L/h derived_from_reported source_1 checked
tizanidine pk_parameter ke_1_per_h 0.2772588722239781 1/h   derived_from_reported - derived_from_pk_yml_source_fields
tizanidine pk_parameter t_half_h 2.5 h 2.5 h label_reported source_1 checked
tizanidine pk_parameter volume 2.4 L/kg 2.4 L/kg literature_reported source_1 checked
tizanidine target targets.auc 858.7470481481926 ng*h/mL   f_dose_over_cl - target_without_source_mapping
tizanidine target targets.t_half 2.5 h   unknown_needs_review - target_without_source_mapping
triazolam model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
triazolam model_parameter model.theta.CL 31.560000000000002 31.560000000000002 L/h derived_from_reported source_3 checked
triazolam model_parameter model.theta.F1 1.0 fraction   fixture_policy - fixture_policy_apparent_parameters
triazolam model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
triazolam model_parameter model.theta.V 159.36009421659492 159.36009421659492 L derived_from_reported source_3 checked
triazolam pk_parameter CL_abs_L_per_h_at_70kg 31.560000000000002 L/h 31.560000000000002 L/h literature_reported source_3 checked
triazolam pk_parameter CL_systemic_L_per_h_at_70kg 13.886400000000002 L/h   derived_from_reported - derived_from_pk_yml_source_fields
triazolam pk_parameter V_abs_L_at_70kg 159.36009421659492 L 159.36009421659492 L derived_from_reported source_3 checked
triazolam pk_parameter V_systemic_L_at_70kg 70.11844145530176 L   derived_from_reported - derived_from_pk_yml_source_fields
triazolam pk_parameter bioavailability 0.44 fraction   - - source_url_present_not_parameter_mapped
triazolam pk_parameter clearance 31.560000000000002 L/h 31.560000000000002 L/h literature_reported source_3 checked
triazolam pk_parameter ke_1_per_h 0.19804205158855578 1/h   derived_from_reported - derived_from_pk_yml_source_fields
triazolam pk_parameter t_half_h 3.5 h 3.5 h derived_from_reported source_1 checked
triazolam pk_parameter volume 159.36009421659492 L 159.36009421659492 L derived_from_reported source_3 checked
triazolam target targets.auc 3168.5678073510776 ng*h/mL   dose_over_cl - derived_target
triazolam target targets.t_half 3.5 h   unknown_needs_review - target_without_source_mapping
verapamil model_parameter model.theta.ALAG1 0.5   fixture_policy - fixture_policy_no_external_source
verapamil model_parameter model.theta.CL 30.0384 30.0384 L/h derived_from_reported source_3 checked
verapamil model_parameter model.theta.F1 0.2247 fraction   fixture_policy - fixture_policy_apparent_parameters
verapamil model_parameter model.theta.KA 1.2   fixture_policy - fixture_policy_no_external_source
verapamil model_parameter model.theta.V 175.7 175.7 L derived_from_reported source_3 checked
verapamil pk_parameter CL_abs_L_per_h_at_70kg 30.0384 L/h 30.0384 L/h literature_reported source_3 checked
verapamil pk_parameter CL_systemic_L_per_h_at_70kg 30.0384 L/h   derived_from_reported - derived_from_pk_yml_source_fields
verapamil pk_parameter V_abs_L_at_70kg 175.7 L 175.7 L literature_reported source_3 checked
verapamil pk_parameter V_systemic_L_at_70kg 175.7 L   derived_from_reported - derived_from_pk_yml_source_fields
verapamil pk_parameter bioavailability 0.2247 fraction   - - source_url_present_not_parameter_mapped
verapamil pk_parameter clearance 30.0384 L/h 30.0384 L/h literature_reported source_3 checked
verapamil pk_parameter ke_1_per_h 0.17096414342629482 1/h   derived_from_reported - derived_from_pk_yml_source_fields
verapamil pk_parameter t_half_h 5.1 h 5.1 h derived_from_reported source_1 checked
verapamil pk_parameter volume 175.7 L 175.7 L literature_reported source_3 checked
verapamil target targets.auc 748.0425055928413 ng*h/mL   f_dose_over_cl - target_without_source_mapping
verapamil target targets.t_half 5.1 h   unknown_needs_review - target_without_source_mapping

ソースURL

Drug Source key URL
abciximab source_1 https://go.drugbank.com/drugs/DB00054
abciximab source_2 https://pubmed.ncbi.nlm.nih.gov/11907493/
abciximab source_3 https://www.researchgate.net/publication/232754238_Pharmacokinetics_PK_pharmacodynamics_PD_and_GPIIBIIIA_receptor_blockade_of_ABCIXIMAB_in_stable_angina_pectoris_patients
abciximab source_4 https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/abciximab
abciximab source_5 https://pubmed.ncbi.nlm.nih.gov/14618072/
abciximab source_6 https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1016/j.clpt.2003.11.342
aciclovir source_1 https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e8a0f9f8-294f-4dd6-bd55-10a6253f1aa8
aciclovir source_2 https://pubmed.ncbi.nlm.nih.gov/6355048/
aciclovir source_3 https://www.sciencedirect.com/science/article/pii/S2590170220300339
aciclovir source_4 https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=69a98000-adef-4323-89a7-09e035a257d4
aciclovir source_5 https://pubmed.ncbi.nlm.nih.gov/7048912/
albuterol source_1 https://pubmed.ncbi.nlm.nih.gov/3790406/
alfentanil source_1 https://dailymed.nlm.nih.gov/dailymed/downloadpdffile.cfm?setId=c965d63f-933b-4a83-88f6-c8c74159530b
alprazolam source_1 https://pubmed.ncbi.nlm.nih.gov/8513649/
amikacin source_1 https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0b56f6df-a05d-4520-8bf0-d7cefe20f6ad
apixaban source_1 https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=095a08ac-cf0e-497e-a682-ddef38d6b29c
atazanavir source_1 https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7fbea274-d6b5-4faa-bbf0-05fefab42114
atazanavir source_2 https://pmc.ncbi.nlm.nih.gov/articles/PMC1635184/
buprenorphine source_2 https://pmc.ncbi.nlm.nih.gov/articles/PMC3663890/
carbamazepine source_1 https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=52f0f753-a70c-4572-a85c-97ea7a2601a9
cda1 source_1 https://pubmed.ncbi.nlm.nih.gov/18502001/
cda1 source_2 https://pmc.ncbi.nlm.nih.gov/articles/PMC2628753/
cimetidine source_1 https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=496e258d-a5fd-42da-9a86-73afc8be359b
cimetidine source_2 https://pubmed.ncbi.nlm.nih.gov/7363531/
clarithromycin source_1 https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b1bdf526-4f16-4130-b614-4cb678f060d7
clarithromycin source_2 https://pubmed.ncbi.nlm.nih.gov/10589373/
clarithromycin source_3 https://journals.asm.org/doi/10.1128/aac.01193-08
dapagliflozin source_1 https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/202293Orig1s000ClinPharmR.pdf
efavirenz source_1 https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=13ca3456-e5bf-4bb1-af95-b1378658a358
efavirenz source_2 https://pubmed.ncbi.nlm.nih.gov/40851704/
erythromycin source_1 https://pmc.ncbi.nlm.nih.gov/articles/PMC3581054/
ethinylestradiol source_1 https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=142c4b90-c9ab-45ce-9172-f1ea7d366686
ethinylestradiol source_2 https://pmc.ncbi.nlm.nih.gov/articles/PMC4285808/
felodipine source_1 https://pubmed.ncbi.nlm.nih.gov/1782737/
felodipine source_2 https://pubmed.ncbi.nlm.nih.gov/3327676/
fluconazole source_1 https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f6e44764-c652-4926-b081-9111c82c7957
fluvoxamine source_1 https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=35b377d9-5b7a-4d8e-b6c1-4291d02f5dae
fluvoxamine source_2 https://link.springer.com/article/10.2165/00003088-199500291-00003
fluvoxamine source_3 https://www.clinpgx.org/pmid/7988100
fluvoxamine source_4 https://psychopharmacologyinstitute.com/section/fluvoxamine-essentials-mechanism-of-action-indications-pharmacokinetics-and-dosing-2051-4052/
fluvoxamine source_5 https://en.wikipedia.org/wiki/Fluvoxamine
fluvoxamine source_6 https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/021519lbl.pdf
fluvoxamine source_7 https://pubmed.ncbi.nlm.nih.gov/9184622/
fluvoxamine source_8 https://go.drugbank.com/drugs/DB00176
inulin source_1 https://go.drugbank.com/drugs/DB00638
inulin source_2 https://www.sciencedirect.com/topics/immunology-and-microbiology/elimination-half-life
inulin source_3 https://pmc.ncbi.nlm.nih.gov/articles/PMC1873801/
itraconazole source_1 https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b1274d78-1096-4ae3-8299-a2e94eaa0ea5
mefenamic_acid source_1 https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=d0291319-ab3e-20c8-e053-2a95a90afabb
mefenamic_acid source_2 https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/015034s046lbl.pdf
metoprolol source_1 https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=cbc32a80-717b-4cf2-b76a-6d03a3720419
metoprolol source_2 https://pubmed.ncbi.nlm.nih.gov/6102500/
mexiletine source_1 https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ab73778b-6794-441c-b127-610a6d0733ea
mexiletine source_2 https://pubmed.ncbi.nlm.nih.gov/10589372/
moclobemide source_1 https://go.drugbank.com/drugs/DB01171
moclobemide source_2 https://pubmed.ncbi.nlm.nih.gov/2248087/
moclobemide source_3 https://pubmed.ncbi.nlm.nih.gov/8582117/
moclobemide source_4 https://en.wikipedia.org/wiki/Moclobemide
moclobemide source_5 https://pubmed.ncbi.nlm.nih.gov/3665338/
montelukast source_1 https://pubmed.ncbi.nlm.nih.gov/9429741/
motavizumab_medi_524 source_1 https://pmc.ncbi.nlm.nih.gov/articles/PMC3837853/
motavizumab_yte source_1 https://pmc.ncbi.nlm.nih.gov/articles/PMC3837853/
omeprazole source_1 https://en.wikipedia.org/wiki/Omeprazole
omeprazole source_2 https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d8b466e0-a35e-4fba-9d43-4e6c0122e7ad
omeprazole source_3 https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a17e415e-a559-4a8d-a455-699184a01523
omeprazole source_4 https://pubmed.ncbi.nlm.nih.gov/2315973/
raltegravir source_1 https://pmc.ncbi.nlm.nih.gov/articles/PMC3370715/
raltegravir source_2 https://pubmed.ncbi.nlm.nih.gov/21746959/
sildenafil source_1 https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=7086e222-0f2b-4c02-84c0-4f8635c90993
sildenafil source_2 https://pmc.ncbi.nlm.nih.gov/articles/PMC1874251/
sildenafil source_3 https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/020895s027lbl.pdf
sildenafil source_4 https://en.wikipedia.org/wiki/Sildenafil
sildenafil source_5 https://go.drugbank.com/drugs/DB00203
sildenafil source_6 https://labeling.pfizer.com/ShowLabeling.aspx?id=14610
sufentanil source_1 https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8b580f3d-e3b5-4086-b093-87a980631147
tefibazumab source_1 https://pmc.ncbi.nlm.nih.gov/articles/PMC1610062/
tizanidine source_1 https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=043d9e51-bfa2-4add-9058-5ece332f7e99
triazolam source_1 https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ce6ddb53-89ca-4edf-a519-553d34ce7938
triazolam source_2 https://go.drugbank.com/drugs/DB00897
triazolam source_3 https://pmc.ncbi.nlm.nih.gov/articles/PMC1401197/
verapamil source_1 https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c9d71191-b32a-44f9-bc5a-283a06884c82
verapamil source_2 https://pubchem.ncbi.nlm.nih.gov/compound/Verapamil
verapamil source_3 https://pubmed.ncbi.nlm.nih.gov/432439/