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"10-20", "raw_unit": "percent", "stored": 0.1, "computed": 0.1, "status": "MATCH", "calculation": "selected raw 10 * factor 0.01", "documented_formula": "lower bound of reported average oral bioavailability range (10% to 20%)" }, { "slug": "aciclovir", "parameter": "t_half_h", "raw_value": "2.5-3.3", "raw_unit": "h", "stored": 2.5, "computed": 2.5, "status": "MATCH", "calculation": "selected raw 2.5 * factor 1", "documented_formula": "lower bound of reported adult half-life range (2.5 to 3.3 h)" }, { "slug": "albuterol", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 480, "raw_unit": "mL/min", "stored": 28.8, "computed": 28.799999999999997, "status": "MATCH", "calculation": "selected raw 480 * factor 0.06", "documented_formula": "480 mL/min * 60 min/h / 1000 mL/L" }, { "slug": "albuterol", "parameter": "V_abs_L_at_70kg", "raw_value": 480, "raw_unit": "mL/min with t1/2 3.86 h", "stored": 160.38152230554428, "computed": 160.38152230554428, "status": "MATCH", "calculation": "V = CL * t_half / ln(2)", "documented_formula": "CL_abs_L_per_h_at_70kg * t_half_h / ln(2)" }, { "slug": "albuterol", "parameter": "t_half_h", "raw_value": 3.86, "raw_unit": "h", "stored": 3.86, "computed": 3.86, "status": "MATCH", "calculation": "selected raw 3.86 * factor 1", "documented_formula": "pk_parsed.half_life_h" }, { "slug": "alfentanil", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 5.0, "raw_unit": "mL/kg/min", "stored": 21.0, "computed": 21.0, "status": "MATCH", "calculation": "selected raw 5 * factor 4.2", "documented_formula": "5 mL/kg/min * 70 kg * 60 min/h / 1000 mL/L" }, { "slug": "alfentanil", "parameter": "V_abs_L_at_70kg", "raw_value": "0.4-1.0", "raw_unit": "L/kg", "stored": 70.0, "computed": 70.0, "status": "MATCH", "calculation": "selected raw 1 * factor 70", "documented_formula": "upper bound of reported apparent volume range (1 L/kg) * 70 kg" }, { "slug": "alfentanil", "parameter": "t_half_h", "raw_value": "90-111", "raw_unit": "min", "stored": 1.675, "computed": 1.675, "status": "MATCH", "calculation": "selected raw 100.5 * factor 0.0166666666666667", "documented_formula": "mean of reported 90-111 min range / 60 min/h" }, { "slug": "alprazolam", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 1.5, "raw_unit": "mL/min/kg", "stored": 6.3, "computed": 6.300000000000001, "status": "MATCH", "calculation": "selected raw 1.5 * factor 4.2", "documented_formula": "1.5 mL/min/kg * 60 min/h / 1000 mL/L * 70 kg" }, { "slug": "alprazolam", "parameter": "V_abs_L_at_70kg", "raw_value": 1.3, "raw_unit": "L/kg", "stored": 91.0, "computed": 91.0, "status": "MATCH", "calculation": "selected raw 1.3 * factor 70", "documented_formula": "1.3 L/kg * 70 kg" }, { "slug": "alprazolam", "parameter": "t_half_h", "raw_value": "9-16", "raw_unit": "h", "stored": 12.5, "computed": 12.5, "status": "MATCH", "calculation": "selected raw 12.5 * factor 1", "documented_formula": "midpoint of reported 9-16 h range" }, { "slug": "amikacin", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 100.0, "raw_unit": "mL/min", "stored": 6.0, "computed": 6.0, "status": "MATCH", "calculation": "selected raw 100 * factor 0.06", "documented_formula": "100 mL/min * 60 min/h / 1000 mL/L" }, { "slug": "amikacin", "parameter": "V_abs_L_at_70kg", "raw_value": 24.0, "raw_unit": "L", "stored": 24.0, "computed": 24.0, "status": "MATCH", "calculation": "selected raw 24 * factor 1", "documented_formula": "pk_parsed.volume.value" }, { "slug": "amikacin", "parameter": "t_half_h", "raw_value": "slightly over 2", "raw_unit": "h", "stored": 2.0, "computed": null, "status": "NOT_EVALUATED", "calculation": "Formula not independently evaluated; see manual review", "documented_formula": "reported \"slightly over 2 hours\" retained as 2.0 h fixture value" }, { "slug": "apixaban", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 3.3, "raw_unit": "L/h", "stored": 3.3, "computed": 3.3, "status": "MATCH", "calculation": "selected raw 3.3 * factor 1", "documented_formula": "pk_parsed.clearance.value" }, { "slug": "apixaban", "parameter": "V_abs_L_at_70kg", "raw_value": "3.3 and 12.0", "raw_unit": "L/h and h", "stored": 57.130723619202946, "computed": 57.130723619202946, "status": "MATCH", "calculation": "V = CL * t_half / ln(2)", "documented_formula": "CL_abs_L_per_h_at_70kg * t_half_h / ln(2)" }, { "slug": "apixaban", "parameter": "t_half_h", "raw_value": 12.0, "raw_unit": "h", "stored": 12.0, "computed": 12.0, "status": "MATCH", "calculation": "selected raw 12 * factor 1", "documented_formula": "pk_parsed.half_life_h" }, { "slug": "atazanavir", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 12.9, "raw_unit": "L/h", "stored": 12.9, "computed": 12.9, "status": "MATCH", "calculation": "selected raw 12.9 * factor 1", "documented_formula": "pk_parsed.clearance.value" }, { "slug": "atazanavir", "parameter": "V_abs_L_at_70kg", "raw_value": 88.3, "raw_unit": "L", "stored": 88.3, "computed": 88.3, "status": "MATCH", "calculation": "selected raw 88.3 * factor 1", "documented_formula": "pk_parsed.volume.value" }, { "slug": "atazanavir", "parameter": "t_half_h", "raw_value": 4.6, "raw_unit": "h", "stored": 4.6, "computed": 4.6, "status": "MATCH", "calculation": "selected raw 4.6 * factor 1", "documented_formula": "pk_parsed.half_life_h" }, { "slug": "buprenorphine", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 54.0, "raw_unit": "L/h", "stored": 54.0, "computed": 54.0, "status": "MATCH", "calculation": "selected raw 54 * factor 1", "documented_formula": "source_2 reported IV clearance" }, { "slug": "buprenorphine", "parameter": "V_abs_L_at_70kg", "raw_value": 806.0, "raw_unit": "L", "stored": 806.0, "computed": 806.0, "status": "MATCH", "calculation": "selected raw 806 * factor 1", "documented_formula": "source_2 reported IV Vd" }, { "slug": "buprenorphine", "parameter": "t_half_h", "raw_value": 54.0, "raw_unit": "L/h", "stored": 10.345863472802147, "computed": 10.345863472802147, "status": "MATCH", "calculation": "t_half = ln(2) * V / CL", "documented_formula": "ln(2) * V / CL = ln(2) * 806 L / 54 L/h" }, { "slug": "carbamazepine", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 80, "raw_unit": "mL/min", "stored": 4.8, "computed": 4.8, "status": "MATCH", "calculation": "selected raw 80 * factor 0.06", "documented_formula": "80 mL/min * 60 min/h / 1000 mL/L" }, { "slug": "carbamazepine", "parameter": "V_abs_L_at_70kg", "raw_value": 80, "raw_unit": "mL/min", "stored": 100.41157484587185, "computed": 100.41157484587185, "status": "MATCH", "calculation": "V = CL * t_half / ln(2)", "documented_formula": "CL_apparent_L_per_h_at_70kg * half_life_h / ln(2)" }, { "slug": "carbamazepine", "parameter": "t_half_h", "raw_value": "12-17", "raw_unit": "h", "stored": 14.5, "computed": 14.5, "status": "MATCH", "calculation": "selected raw 14.5 * factor 1", "documented_formula": "(12 h + 17 h) / 2" }, { "slug": "cda1", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 0.0014, "raw_unit": "mL/min/kg", "stored": 0.00588, "computed": 0.00588, "status": "MATCH", "calculation": "selected raw 0.0014 * factor 4.2", "documented_formula": "0.0014 mL/min/kg * 60 min/h / 1000 mL/L * 70 kg" }, { "slug": "cda1", "parameter": "V_abs_L_at_70kg", "raw_value": 0.07, "raw_unit": "L/kg", "stored": 4.9, "computed": 4.9, "status": "MATCH", "calculation": "selected raw 0.07 * factor 70", "documented_formula": "0.070 L/kg * 70 kg" }, { "slug": "cda1", "parameter": "t_half_h", "raw_value": "25.3-31.8", "raw_unit": "days", "stored": 685.2, "computed": 685.2, "status": "MATCH", "calculation": "selected raw 28.55 * factor 24", "documented_formula": "fixture midpoint 28.55 days * 24 h/day" }, { "slug": "cimetidine", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 495, "raw_unit": "mL/min", "stored": 29.7, "computed": 29.7, "status": "MATCH", "calculation": "selected raw 495 * factor 0.06", "documented_formula": "495 mL/min * 60 min/h / 1000 mL/L" }, { "slug": "cimetidine", "parameter": "V_abs_L_at_70kg", "raw_value": 0.8, "raw_unit": "L/kg", "stored": 56.0, "computed": 56.0, "status": "MATCH", "calculation": "selected raw 0.8 * factor 70", "documented_formula": "pk_parsed.volume.value * pk_parsed.weight_ref_kg_for_abs" }, { "slug": "cimetidine", "parameter": "bioavailability_frac", "raw_value": 60, "raw_unit": "percent", "stored": 0.6, "computed": 0.6, "status": "MATCH", "calculation": "selected raw 60 * factor 0.01", "documented_formula": "60 percent / 100" }, { "slug": "cimetidine", "parameter": "t_half_h", "raw_value": 2.0, "raw_unit": "h", "stored": 2.0, "computed": 2.0, "status": "MATCH", "calculation": "selected raw 2 * factor 1", "documented_formula": "pk_parsed.half_life_h" }, { "slug": "clarithromycin", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 58.1, "raw_unit": "L/h", "stored": 58.1, "computed": 58.1, "status": "MATCH", "calculation": "selected raw 58.1 * factor 1", "documented_formula": "pk_parsed.clearance.value" }, { "slug": "clarithromycin", "parameter": "V_abs_L_at_70kg", "raw_value": 172.0, "raw_unit": "L", "stored": 172.0, "computed": 172.0, "status": "MATCH", "calculation": "selected raw 172 * factor 1", "documented_formula": "pk_parsed.volume.value" }, { "slug": "clarithromycin", "parameter": "t_half_h", "raw_value": "3-7", "raw_unit": "h", "stored": 5.0, "computed": 5.0, "status": "MATCH", "calculation": "selected raw 5 * factor 1", "documented_formula": "midpoint of reported terminal half-life range (3 to 7 h)" }, { "slug": "dapagliflozin", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 207, "raw_unit": "mL/min", "stored": 12.42, "computed": 12.42, "status": "MATCH", "calculation": "selected raw 207 * factor 0.06", "documented_formula": "207 mL/min * 60 min/h / 1000 mL/L" }, { "slug": "dapagliflozin", "parameter": "V_abs_L_at_70kg", "raw_value": 118, "raw_unit": "L", "stored": 118.0, "computed": 118.0, "status": "MATCH", "calculation": "selected raw 118 * factor 1", "documented_formula": "FDA source_1 Table 24 reported Vss" }, { "slug": "dapagliflozin", "parameter": "bioavailability_frac", "raw_value": 77.8, "raw_unit": "percent", "stored": 0.78, "computed": 0.778, "status": "MISMATCH", "calculation": "selected raw 77.8 * factor 0.01", "documented_formula": "77.8 percent / 100" }, { "slug": "dapagliflozin", "parameter": "t_half_h", "raw_value": 12.9, "raw_unit": "h", "stored": 12.9, "computed": 12.9, "status": "MATCH", "calculation": "selected raw 12.9 * factor 1", "documented_formula": "FDA source_1 reported oral terminal t1/2" }, { "slug": "efavirenz", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 13.9, "raw_unit": "L/h", "stored": 13.9, "computed": 13.9, "status": "MATCH", "calculation": "selected raw 13.9 * factor 1", "documented_formula": "source_2 reported typical oral CL/F" }, { "slug": "efavirenz", "parameter": "V_abs_L_at_70kg", "raw_value": 13.9, "raw_unit": "L/h", "stored": 1163.1007419646824, "computed": 1163.1007419646824, "status": "MATCH", "calculation": "V = CL * t_half / ln(2)", "documented_formula": "CL_apparent_L_per_h_at_70kg * half_life_h / ln(2)" }, { "slug": "efavirenz", "parameter": "t_half_h", "raw_value": "52-76", "raw_unit": "h", "stored": 58.0, "computed": null, "status": "NOT_EVALUATED", "calculation": "Formula not independently evaluated; see manual review", "documented_formula": "single-dose range is retained; current 58 h is the fixture representative" }, { "slug": "erythromycin", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 0.53, "raw_unit": "L/h/kg", "stored": 37.1, "computed": 37.1, "status": "MATCH", "calculation": "selected raw 0.53 * factor 70", "documented_formula": "0.53 L/h/kg * 70 kg" }, { "slug": "erythromycin", "parameter": "V_abs_L_at_70kg", "raw_value": "0.53 and 2.30", "raw_unit": "L/h/kg and h", "stored": 123.10516783905524, "computed": 123.10516783905526, "status": "MATCH", "calculation": "V = CL * t_half / ln(2)", "documented_formula": "CL_abs_L_per_h_at_70kg * t_half_h / ln(2)" }, { "slug": "erythromycin", "parameter": "t_half_h", "raw_value": 2.3, "raw_unit": "h", "stored": 2.3, "computed": 2.3, "status": "MATCH", "calculation": "selected raw 2.3 * factor 1", "documented_formula": "pk_parsed.half_life_h" }, { "slug": "ethinylestradiol", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 25.7, "raw_unit": "L/h", "stored": 25.7, "computed": 25.7, "status": "MATCH", "calculation": "selected raw 25.7 * factor 1", "documented_formula": "pk_parsed.clearance.value" }, { "slug": "ethinylestradiol", "parameter": "V_abs_L_at_70kg", "raw_value": "25.7 and 17.05", "raw_unit": "L/h and h", "stored": 632.1673264919305, "computed": 632.1673264919305, "status": "MATCH", "calculation": "V = CL * t_half / ln(2)", "documented_formula": "CL_abs_L_per_h_at_70kg * t_half_h / ln(2)" }, { "slug": "ethinylestradiol", "parameter": "t_half_h", "raw_value": "16.5-17.6", "raw_unit": "h", "stored": 17.05, "computed": 17.05, "status": "MATCH", "calculation": "selected raw 17.05 * factor 1", "documented_formula": "midpoint of reported 16.5-17.6 h range" }, { "slug": "felodipine", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": "1-1.5", "raw_unit": "L/min", "stored": 90.0, "computed": 90.0, "status": "MATCH", "calculation": "selected raw 1.5 * factor 60", "documented_formula": "upper bound of reported clearance range (1.5 L/min) * 60 min/h" }, { "slug": "felodipine", "parameter": "V_abs_L_at_70kg", "raw_value": 10.0, "raw_unit": "L/kg", "stored": 700.0, "computed": 700.0, "status": "MATCH", "calculation": "selected raw 10 * factor 70", "documented_formula": "pk_parsed.volume.value * pk_parsed.weight_ref_kg_for_abs" }, { "slug": "felodipine", "parameter": "bioavailability_frac", "raw_value": 15, "raw_unit": "percent", "stored": 0.15, "computed": 0.15, "status": "MATCH", "calculation": "selected raw 15 * factor 0.01", "documented_formula": "15 percent / 100" }, { "slug": "felodipine", "parameter": "t_half_h", "raw_value": "approximately 25", "raw_unit": "h", "stored": 24.5, "computed": null, "status": "NOT_EVALUATED", "calculation": "Formula not independently evaluated; see manual review", "documented_formula": "fixture midpoint of local 24-25 h range, source-confirmed as approximately 25 h" }, { "slug": "fluconazole", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 0.23, "raw_unit": "mL/min/kg", "stored": 0.966, "computed": 0.9660000000000001, "status": "MATCH", "calculation": "selected raw 0.23 * factor 4.2", "documented_formula": "0.23 mL/min/kg * 60 min/h / 1000 mL/L * 70 kg" }, { "slug": "fluconazole", "parameter": "V_abs_L_at_70kg", "raw_value": "0.23 and 30.0", "raw_unit": "mL/min/kg and h", "stored": 41.80930228496216, "computed": 41.809302284962165, "status": "MATCH", "calculation": "V = CL * t_half / ln(2)", "documented_formula": "CL_abs_L_per_h_at_70kg * t_half_h / ln(2)" }, { "slug": "fluconazole", "parameter": "t_half_h", "raw_value": 30.0, "raw_unit": "h", "stored": 30.0, "computed": 30.0, "status": "MATCH", "calculation": "selected raw 30 * factor 1", "documented_formula": "pk_parsed.half_life_h" }, { "slug": "fluvoxamine", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 25.0, "raw_unit": "L/kg", "stored": 65.56797653945428, "computed": 65.56797653945428, "status": "MATCH", "calculation": "CL = V * ln(2) / t_half", "documented_formula": "(25 L/kg * 70 kg) * ln(2) / 18.5 h" }, { "slug": "fluvoxamine", "parameter": "V_abs_L_at_70kg", "raw_value": 25.0, "raw_unit": "L/kg", "stored": 1750.0, "computed": 1750.0, "status": "MATCH", "calculation": "selected raw 25 * factor 70", "documented_formula": "25 L/kg * 70 kg" }, { "slug": "fluvoxamine", "parameter": "t_half_h", "raw_value": "9-28", "raw_unit": "h", "stored": 18.5, "computed": 18.5, "status": "MATCH", "calculation": "selected raw 18.5 * factor 1", "documented_formula": "(9 h + 28 h) / 2" }, { "slug": "inulin", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 93.5, "raw_unit": "mL/min", "stored": 5.61, "computed": 5.609999999999999, "status": "MATCH", "calculation": "selected raw 93.5 * factor 0.06", "documented_formula": "93.5 mL/min * 60 min/h / 1000 mL/L" }, { "slug": "inulin", "parameter": "V_abs_L_at_70kg", "raw_value": 13.0, "raw_unit": "L/70 kg", "stored": 13.0, "computed": 13.0, "status": "MATCH", "calculation": "selected raw 13 * factor 1", "documented_formula": "source_3 reports Vss approximately 13 L/70 kg" }, { "slug": "inulin", "parameter": "t_half_h", "raw_value": 1.6062234130622617, "raw_unit": "h", "stored": 1.6062234130622617, "computed": 1.6062234130622617, "status": "MATCH", "calculation": "t_half = ln(2) * V / CL", "documented_formula": "ln(2) * 13 L / 5.61 L/h" }, { "slug": "itraconazole", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 278.0, "raw_unit": "mL/min", "stored": 16.68, "computed": 16.68, "status": "MATCH", "calculation": "selected raw 278 * factor 0.06", "documented_formula": "278 mL/min * 60 min/h / 1000 mL/L" }, { "slug": "itraconazole", "parameter": "V_abs_L_at_70kg", "raw_value": ">700", "raw_unit": "L", "stored": 700.0, "computed": null, "status": "NOT_EVALUATED", "calculation": "Formula not independently evaluated; see manual review", "documented_formula": "lower bound of reported apparent volume (>700 L)" }, { "slug": "itraconazole", "parameter": "bioavailability_frac", "raw_value": 55, "raw_unit": "percent", "stored": 0.55, "computed": 0.55, "status": "MATCH", "calculation": "selected raw 55 * factor 0.01", "documented_formula": "55 percent / 100" }, { "slug": "itraconazole", "parameter": "t_half_h", "raw_value": "16-28", "raw_unit": "h", "stored": 22.0, "computed": 22.0, "status": "MATCH", "calculation": "selected raw 22 * factor 1", "documented_formula": "midpoint of reported single-dose terminal half-life range (16 to 28 h)" }, { "slug": "mefenamic_acid", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 21.13, "raw_unit": "L/h", "stored": 21.13, "computed": 21.13, "status": "MATCH", "calculation": "selected raw 21.13 * factor 1", "documented_formula": "pk_parsed.clearance.value" }, { "slug": "mefenamic_acid", "parameter": "V_abs_L_at_70kg", "raw_value": 1.06, "raw_unit": "L/kg", "stored": 74.2, "computed": 74.2, "status": "MATCH", "calculation": "selected raw 1.06 * factor 70", "documented_formula": "1.06 L/kg * 70 kg" }, { "slug": "mefenamic_acid", "parameter": "t_half_h", "raw_value": "2-4", "raw_unit": "h", "stored": 3.0, "computed": 3.0, "status": "MATCH", "calculation": "selected raw 3 * factor 1", "documented_formula": "midpoint of reported 2-4 h range" }, { "slug": "metoprolol", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 0.8, "raw_unit": "L/min", "stored": 48.0, "computed": 48.0, "status": "MATCH", "calculation": "selected raw 0.8 * factor 60", "documented_formula": "0.8 L/min * 60 min/h" }, { "slug": "metoprolol", "parameter": "V_abs_L_at_70kg", "raw_value": 346.2468098133512, "raw_unit": "L", "stored": 346.2468098133512, "computed": 346.2468098133512, "status": "MATCH", "calculation": "V = CL * t_half / ln(2)", "documented_formula": "CL_abs_L_per_h_at_70kg * half_life_h / ln(2)" }, { "slug": "metoprolol", "parameter": "bioavailability_frac", "raw_value": 50, "raw_unit": "percent", "stored": 0.5, "computed": 0.5, "status": "MATCH", "calculation": "selected raw 50 * factor 0.01", "documented_formula": "50 percent / 100" }, { "slug": "metoprolol", "parameter": "t_half_h", "raw_value": 5.0, "raw_unit": "h", "stored": 5.0, "computed": 5.0, "status": "MATCH", "calculation": "selected raw 5 * factor 1", "documented_formula": "(3 h + 7 h) / 2" }, { "slug": "mexiletine", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 7.0, "raw_unit": "L/kg", "stored": 30.87655622494302, "computed": 30.87655622494302, "status": "MATCH", "calculation": "CL = V * ln(2) / t_half", "documented_formula": "(7 L/kg * 70 kg) * ln(2) / 11 h" }, { "slug": "mexiletine", "parameter": "V_abs_L_at_70kg", "raw_value": 7.0, "raw_unit": "L/kg", "stored": 490.0, "computed": 490.0, "status": "MATCH", "calculation": "selected raw 7 * factor 70", "documented_formula": "7 L/kg * 70 kg" }, { "slug": "mexiletine", "parameter": "t_half_h", "raw_value": "10-12", "raw_unit": "h", "stored": 11.0, "computed": 11.0, "status": "MATCH", "calculation": "selected raw 11 * factor 1", "documented_formula": "(10 h + 12 h) / 2" }, { "slug": "moclobemide", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 39.4, "raw_unit": "L/h", "stored": 39.4, "computed": 39.4, "status": "MATCH", "calculation": "selected raw 39.4 * factor 1", "documented_formula": "source_5 first IV infusion clearance" }, { "slug": "moclobemide", "parameter": "V_abs_L_at_70kg", "raw_value": 84.3, "raw_unit": "L", "stored": 84.3, "computed": 84.3, "status": "MATCH", "calculation": "selected raw 84.3 * factor 1", "documented_formula": "source_5 first IV infusion Vss" }, { "slug": "moclobemide", "parameter": "t_half_h", "raw_value": 1.6, "raw_unit": "h", "stored": 1.6, "computed": 1.6, "status": "MATCH", "calculation": "selected raw 1.6 * factor 1", "documented_formula": "source_5 first IV infusion elimination half-life" }, { "slug": "moclobemide", "parameter": "bioavailability_frac", "raw_value": 0.56, "raw_unit": "fraction", "stored": 0.56, "computed": 0.56, "status": "MATCH", "calculation": "selected raw 0.56 * factor 1", "documented_formula": "source_5 first oral dose absolute bioavailability" }, { "slug": "montelukast", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 30.8, "raw_unit": "mL/min", "stored": 1.8479999999999999, "computed": 1.8479999999999999, "status": "MATCH", "calculation": "selected raw 30.8 * factor 0.06", "documented_formula": "30.8 mL/min * 60 min/h / 1000 mL/L" }, { "slug": "montelukast", "parameter": "V_abs_L_at_70kg", "raw_value": 9.7, "raw_unit": "L", "stored": 9.7, "computed": 9.7, "status": "MATCH", "calculation": "selected raw 9.7 * factor 1", "documented_formula": "pk_parsed.volume.value" }, { "slug": "montelukast", "parameter": "t_half_h", "raw_value": 6.7, "raw_unit": "h", "stored": 6.7, "computed": 6.7, "status": "MATCH", "calculation": "selected raw 6.7 * factor 1", "documented_formula": "pk_parsed.half_life_h" }, { "slug": "montelukast", "parameter": "bioavailability_frac", "raw_value": "61-62", "raw_unit": "percent", "stored": 0.615, "computed": 0.615, "status": "MATCH", "calculation": "selected raw 61.5 * factor 0.01", "documented_formula": "midpoint of healthy elderly and healthy young oral bioavailability (61% and 62%)" }, { "slug": "motavizumab_medi_524", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": "165-326", "raw_unit": "mL/day", "stored": 0.010229166666666666, "computed": 0.010229166666666666, "status": "MATCH", "calculation": "selected raw 245.5 * factor 4.16666666666667e-05", "documented_formula": "midpoint of 165-326 mL/day * 1 L/1000 mL / 24 h/day" }, { "slug": "motavizumab_medi_524", "parameter": "V_abs_L_at_70kg", "raw_value": "5.2-9.5", "raw_unit": "L", "stored": 7.35, "computed": 7.35, "status": "MATCH", "calculation": "selected raw 7.35 * factor 1", "documented_formula": "midpoint of reported 5.2-9.5 L range" }, { "slug": "motavizumab_medi_524", "parameter": "t_half_h", "raw_value": "19-34", "raw_unit": "days", "stored": 636.0, "computed": 636.0, "status": "MATCH", "calculation": "selected raw 26.5 * factor 24", "documented_formula": "midpoint of reported 19-34 days * 24 h/day" }, { "slug": "motavizumab_yte", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": "43-68", "raw_unit": "mL/day", "stored": 0.0022916666666666667, "computed": 0.0023125, "status": "MISMATCH", "calculation": "selected raw 55.5 * factor 4.16666666666667e-05", "documented_formula": "midpoint of 43-68 mL/day * 1 L/1000 mL / 24 h/day" }, { "slug": "motavizumab_yte", "parameter": "V_abs_L_at_70kg", "raw_value": "55 and 85", "raw_unit": "mL/day and days", "stored": 6.744599316155904, "computed": 6.744599316155904, "status": "MATCH", "calculation": "V = CL * t_half / ln(2)", "documented_formula": "CL_abs_L_per_h_at_70kg * t_half_h / ln(2)" }, { "slug": "motavizumab_yte", "parameter": "t_half_h", "raw_value": "70-100", "raw_unit": "days", "stored": 2040, "computed": 2040.0, "status": "MATCH", "calculation": "selected raw 85 * factor 24", "documented_formula": "midpoint of reported 70-100 days * 24 h/day" }, { "slug": "omeprazole", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 624, "raw_unit": "mL/min", "stored": 43.56, "computed": 37.44, "status": "MISMATCH", "calculation": "selected raw 624 * factor 0.06", "documented_formula": "624 mL/min * 60 min/h / 1000 mL/L" }, { "slug": "omeprazole", "parameter": "V_abs_L_at_70kg", "raw_value": 0.23, "raw_unit": "L/kg", "stored": 16.1, "computed": 16.1, "status": "MATCH", "calculation": "selected raw 0.23 * factor 70", "documented_formula": "0.23 L/kg * 70 kg" }, { "slug": "omeprazole", "parameter": "bioavailability_frac", "raw_value": "30-40", "raw_unit": "percent", "stored": 0.35, "computed": 0.35000000000000003, "status": "MATCH", "calculation": "selected raw 35 * factor 0.01", "documented_formula": "midpoint of healthy-subject label range (30% to 40%) at 20-40 mg" }, { "slug": "omeprazole", "parameter": "t_half_h", "raw_value": "0.5-1.0", "raw_unit": "h", "stored": 0.75, "computed": null, "status": "NOT_EVALUATED", "calculation": "Formula not independently evaluated; see manual review", "documented_formula": "fixture value retained within reported plasma half-life range (0.5 to 1 h)" }, { "slug": "raltegravir", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 60.2, "raw_unit": "L/h", "stored": 60.2, "computed": 60.2, "status": "MATCH", "calculation": "selected raw 60.2 * factor 1", "documented_formula": "source_1 reported oral CL/F" }, { "slug": "raltegravir", "parameter": "V_abs_L_at_70kg", "raw_value": 677.4318833998217, "raw_unit": "L", "stored": 677.4318833998217, "computed": 677.4318833998217, "status": "MATCH", "calculation": "V = CL * t_half / ln(2)", "documented_formula": "CL_abs_L_per_h_at_70kg * half_life_h / ln(2)" }, { "slug": "raltegravir", "parameter": "t_half_h", "raw_value": 7.8, "raw_unit": "h", "stored": 7.8, "computed": 7.8, "status": "MATCH", "calculation": "selected raw 7.8 * factor 1", "documented_formula": "source_2 reported geometric-mean apparent plasma half-life" }, { "slug": "sildenafil", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": "105 and 4.0", "raw_unit": "L and h", "stored": 18.195113489698564, "computed": 18.195113489698564, "status": "MATCH", "calculation": "CL = V * ln(2) / t_half", "documented_formula": "V_abs_L_at_70kg * ln(2) / t_half_h" }, { "slug": "sildenafil", "parameter": "V_abs_L_at_70kg", "raw_value": 105, "raw_unit": "L", "stored": 105.0, "computed": 105.0, "status": "MATCH", "calculation": "selected raw 105 * factor 1", "documented_formula": "pk_parsed.volume.value" }, { "slug": "sildenafil", "parameter": "t_half_h", "raw_value": "3-5", "raw_unit": "h", "stored": 4.0, "computed": 4.0, "status": "MATCH", "calculation": "selected raw 4 * factor 1", "documented_formula": "midpoint of reported 3-5 h range" }, { "slug": "sufentanil", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 108, "raw_unit": "L/h", "stored": 108.0, "computed": 108.0, "status": "MATCH", "calculation": "selected raw 108 * factor 1", "documented_formula": "pk_parsed.clearance.value" }, { "slug": "sufentanil", "parameter": "V_abs_L_at_70kg", "raw_value": 108, "raw_unit": "L/h", "stored": 2087.868263174508, "computed": 2087.868263174508, "status": "MATCH", "calculation": "V = CL * t_half / ln(2)", "documented_formula": "CL_apparent / (ln(2) / terminal_half_life)" }, { "slug": "sufentanil", "parameter": "t_half_h", "raw_value": 13.4, "raw_unit": "h", "stored": 13.4, "computed": 13.4, "status": "MATCH", "calculation": "selected raw 13.4 * factor 1", "documented_formula": "pk_parsed.half_life_h" }, { "slug": "sufentanil", "parameter": "bioavailability_frac", "raw_value": 53, "raw_unit": "percent", "stored": 0.53, "computed": 0.53, "status": "MATCH", "calculation": "selected raw 53 * factor 0.01", "documented_formula": "53 / 100" }, { "slug": "tefibazumab", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 12, "raw_unit": "mL/h", "stored": 0.012, "computed": 0.012, "status": "MATCH", "calculation": "selected raw 12 * factor 0.001", "documented_formula": "12 mL/h / 1000 mL/L" }, { "slug": "tefibazumab", "parameter": "V_abs_L_at_70kg", "raw_value": 7.3, "raw_unit": "L", "stored": 7.3, "computed": 7.3, "status": "MATCH", "calculation": "selected raw 7.3 * factor 1", "documented_formula": "source_1 reported IV volume of distribution" }, { "slug": "tefibazumab", "parameter": "t_half_h", "raw_value": "17-18", "raw_unit": "days", "stored": 420.0, "computed": 420.0, "status": "MATCH", "calculation": "selected raw 17.5 * factor 24", "documented_formula": "((17 days + 18 days) / 2) * 24 h/day" }, { "slug": "tizanidine", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 46.579490533628324, "raw_unit": "L/h", "stored": 46.579490533628324, "computed": 46.579490533628324, "status": "MATCH", "calculation": "CL = V * ln(2) / t_half", "documented_formula": "2.4 L/kg * 70 kg * ln(2) / 2.5 h" }, { "slug": "tizanidine", "parameter": "V_abs_L_at_70kg", "raw_value": 2.4, "raw_unit": "L/kg", "stored": 168.0, "computed": 168.0, "status": "MATCH", "calculation": "selected raw 2.4 * factor 70", "documented_formula": "2.4 L/kg * 70 kg" }, { "slug": "tizanidine", "parameter": "bioavailability_frac", "raw_value": 40, "raw_unit": "percent", "stored": 0.4, "computed": 0.4, "status": "MATCH", "calculation": "selected raw 40 * factor 0.01", "documented_formula": "40 percent / 100" }, { "slug": "tizanidine", "parameter": "t_half_h", "raw_value": 2.5, "raw_unit": "h", "stored": 2.5, "computed": 2.5, "status": "MATCH", "calculation": "selected raw 2.5 * factor 1", "documented_formula": "pk_parsed.half_life_h" }, { "slug": "triazolam", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 526, "raw_unit": "mL/min", "stored": 31.56, "computed": 31.56, "status": "MATCH", "calculation": "selected raw 526 * factor 0.06", "documented_formula": "526 mL/min * 60 min/h / 1000 mL/L" }, { "slug": "triazolam", "parameter": "V_abs_L_at_70kg", "raw_value": 31.56, "raw_unit": "L/h", "stored": 159.36009421659492, "computed": 159.36009421659492, "status": "MATCH", "calculation": "V = CL * t_half / ln(2)", "documented_formula": "CL_apparent / (ln(2) / selected_fixture_half_life)" }, { "slug": "triazolam", "parameter": "t_half_h", "raw_value": "1.5-5.5", "raw_unit": "h", "stored": 3.5, "computed": 3.5, "status": "MATCH", "calculation": "selected raw 3.5 * factor 1", "documented_formula": "midpoint of DailyMed reported range (1.5 to 5.5 h)" }, { "slug": "verapamil", "parameter": "CL_abs_L_per_h_at_70kg", "raw_value": 500.64, "raw_unit": "mL/min", "stored": 30.0384, "computed": 30.0384, "status": "MATCH", "calculation": "selected raw 500.64 * factor 0.06", "documented_formula": "500.64 mL/min * 60 min/h / 1000 mL/L" }, { "slug": "verapamil", "parameter": "V_abs_L_at_70kg", "raw_value": 2.51, "raw_unit": "L/kg", "stored": 175.7, "computed": 175.7, "status": "MATCH", "calculation": "selected raw 2.51 * factor 70", "documented_formula": "2.51 L/kg * 70 kg" }, { "slug": "verapamil", "parameter": "bioavailability_frac", "raw_value": 22.47, "raw_unit": "percent", "stored": 0.2247, "computed": 0.22469999999999998, "status": "MATCH", "calculation": "selected raw 22.47 * factor 0.01", "documented_formula": "22.47 percent / 100" }, { "slug": "verapamil", "parameter": "t_half_h", "raw_value": "2.8-7.4", "raw_unit": "h", "stored": 5.1, "computed": 5.1, "status": "MATCH", "calculation": "selected raw 5.1 * factor 1", "documented_formula": "midpoint of reported single-dose terminal half-life range (2.8 to 7.4 h)" } ], "limitations": [ "Internal arithmetic matches do not prove source accuracy or clinical validity.", "25% is a repository warning threshold, not a clinical acceptance criterion.", "Unparsed formulas require manual review; no blanket arithmetic pass is claimed.", "Scalar inventory does not establish external validation for any parameter." ] }