<?xml version="1.0" encoding="UTF-8"?>
<mxfile host="drawio" version="26.0.0">
  <diagram name="PK dummy workflow">
    <mxGraphModel dx="1600" dy="900" grid="1" gridSize="10" guides="1" tooltips="1" connect="1" arrows="1" fold="1" page="1" pageScale="1" pageWidth="2800" pageHeight="1000" math="0" shadow="0">
      <root>
        <mxCell id="0" />
        <mxCell id="1" parent="0" />

        <mxCell id="2" value="開始" style="ellipse;whiteSpace=wrap;html=1;fillColor=#d5e8d4;strokeColor=#82b366;fontStyle=1;fontSize=15;" vertex="1" parent="1">
          <mxGeometry x="40" y="205" width="110" height="60" as="geometry" />
        </mxCell>
        <mxCell id="3" value="YAML仕様・設定&#xa;spec_pk1_*.yml&#xa;DM / EX / PC契約" style="shape=parallelogram;perimeter=parallelogramPerimeter;whiteSpace=wrap;html=1;fillColor=#ffe6cc;strokeColor=#d79b00;fontSize=14;" vertex="1" parent="1">
          <mxGeometry x="200" y="175" width="220" height="120" as="geometry" />
        </mxCell>
        <mxCell id="4" value="試験デザイン" style="rhombus;whiteSpace=wrap;html=1;fillColor=#fff2cc;strokeColor=#d6b656;fontStyle=1;fontSize=14;" vertex="1" parent="1">
          <mxGeometry x="480" y="190" width="170" height="90" as="geometry" />
        </mxCell>
        <mxCell id="5" value="単回投与シミュレーション&#xa;analytical_demo または mrgsolve&#xa;経口 / IV / IV点滴" style="rounded=0;whiteSpace=wrap;html=1;fillColor=#dae8fc;strokeColor=#6c8ebf;fontSize=14;" vertex="1" parent="1">
          <mxGeometry x="710" y="70" width="230" height="110" as="geometry" />
        </mxCell>
        <mxCell id="6" value="反復経口投与シミュレーション&#xa;投与イベントを保持&#xa;dosing_events.csv" style="rounded=0;whiteSpace=wrap;html=1;fillColor=#e1d5e7;strokeColor=#9673a6;fontSize=14;" vertex="1" parent="1">
          <mxGeometry x="710" y="300" width="230" height="110" as="geometry" />
        </mxCell>
        <mxCell id="7" value="raw/sim_full.csv&#xa;密な濃度時系列&#xa;（反復ではdose eventも管理）" style="shape=parallelogram;perimeter=parallelogramPerimeter;whiteSpace=wrap;html=1;fillColor=#ffe6cc;strokeColor=#d79b00;fontSize=14;" vertex="1" parent="1">
          <mxGeometry x="1000" y="180" width="230" height="100" as="geometry" />
        </mxCell>
        <mxCell id="8" value="clinical_samples.csv&#xa;名目採血時点を抽出&#xa;（exact / nearest / linear）" style="rounded=0;whiteSpace=wrap;html=1;fillColor=#dae8fc;strokeColor=#6c8ebf;fontSize=14;" vertex="1" parent="1">
          <mxGeometry x="1290" y="180" width="220" height="100" as="geometry" />
        </mxCell>
        <mxCell id="9" value="SDTM-like domains&#xa;DM / EX / PC&#xa;＋単位・時刻・ROW_ORDER" style="rounded=0;whiteSpace=wrap;html=1;fillColor=#dae8fc;strokeColor=#6c8ebf;fontSize=14;" vertex="1" parent="1">
          <mxGeometry x="1570" y="180" width="220" height="100" as="geometry" />
        </mxCell>
        <mxCell id="10" value="Analysis inputs&#xa;ADPC / NCA_INPUT / POPPK_INPUT&#xa;反復: TROUGH / NCA_SS" style="rounded=0;whiteSpace=wrap;html=1;fillColor=#dae8fc;strokeColor=#6c8ebf;fontSize=14;" vertex="1" parent="1">
          <mxGeometry x="1850" y="180" width="240" height="100" as="geometry" />
        </mxCell>
        <mxCell id="11" value="ADNCA・濃度プロット&#xa;単回: AUC / Cmax / Tmax / λz&#xa;反復: AUCτ,ss / trough / Cmin" style="rounded=0;whiteSpace=wrap;html=1;fillColor=#e1d5e7;strokeColor=#9673a6;fontSize=14;" vertex="1" parent="1">
          <mxGeometry x="2150" y="180" width="250" height="100" as="geometry" />
        </mxCell>
        <mxCell id="12" value="完了&#xa;MANIFEST.yml&#xa;trace.log / validation report" style="ellipse;whiteSpace=wrap;html=1;fillColor=#d5e8d4;strokeColor=#82b366;fontStyle=1;fontSize=14;" vertex="1" parent="1">
          <mxGeometry x="2460" y="195" width="190" height="70" as="geometry" />
        </mxCell>
        <mxCell id="13" value="反復投与の注意: dosing_events.csv を投与イベントの正本にする。&#xa;反復rawを単回用 run_workflow.py validatorへ直接渡さない。" style="rounded=1;whiteSpace=wrap;html=1;fillColor=#f5f5f5;strokeColor=#666666;fontColor=#444444;fontSize=13;align=left;spacingLeft=10;" vertex="1" parent="1">
          <mxGeometry x="980" y="350" width="540" height="70" as="geometry" />
        </mxCell>

        <mxCell id="20" value="" style="html=1;endArrow=block;rounded=0;" edge="1" parent="1" source="2" target="3">
          <mxGeometry relative="1" as="geometry" />
        </mxCell>
        <mxCell id="21" value="" style="html=1;endArrow=block;rounded=0;" edge="1" parent="1" source="3" target="4">
          <mxGeometry relative="1" as="geometry" />
        </mxCell>
        <mxCell id="22" value="単回" style="html=1;endArrow=block;rounded=0;labelBackgroundColor=#ffffff;fontSize=13;" edge="1" parent="1" source="4" target="5">
          <mxGeometry relative="1" as="geometry" />
        </mxCell>
        <mxCell id="23" value="反復" style="html=1;endArrow=block;rounded=0;labelBackgroundColor=#ffffff;fontSize=13;" edge="1" parent="1" source="4" target="6">
          <mxGeometry relative="1" as="geometry" />
        </mxCell>
        <mxCell id="24" value="" style="html=1;endArrow=block;rounded=0;" edge="1" parent="1" source="5" target="7">
          <mxGeometry relative="1" as="geometry" />
        </mxCell>
        <mxCell id="25" value="" style="html=1;endArrow=block;rounded=0;" edge="1" parent="1" source="6" target="7">
          <mxGeometry relative="1" as="geometry" />
        </mxCell>
        <mxCell id="26" value="" style="html=1;endArrow=block;rounded=0;" edge="1" parent="1" source="7" target="8">
          <mxGeometry relative="1" as="geometry" />
        </mxCell>
        <mxCell id="27" value="" style="html=1;endArrow=block;rounded=0;" edge="1" parent="1" source="8" target="9">
          <mxGeometry relative="1" as="geometry" />
        </mxCell>
        <mxCell id="28" value="" style="html=1;endArrow=block;rounded=0;" edge="1" parent="1" source="9" target="10">
          <mxGeometry relative="1" as="geometry" />
        </mxCell>
        <mxCell id="29" value="" style="html=1;endArrow=block;rounded=0;" edge="1" parent="1" source="10" target="11">
          <mxGeometry relative="1" as="geometry" />
        </mxCell>
        <mxCell id="30" value="" style="html=1;endArrow=block;rounded=0;" edge="1" parent="1" source="11" target="12">
          <mxGeometry relative="1" as="geometry" />
        </mxCell>
      </root>
    </mxGraphModel>
  </diagram>
</mxfile>
